Vol 33, No 2 (2016)

Articles
INFLUENCE OF REFRACTORY SUSCEPTIBILITY OF BARORECEPTORS ON DEVELOPMENT OF ARTERIAL HYPERTENSION IN PATIENTS FOLLOWING AORTAL COARCTATION CORRECTION
Soinov I.A., Sinelnikov Y.S., Kornilov I.A., Plotnikova T.A., Gasanov E.N., Kulyabin Y.Y., Omelchenko A.Y., Orekhova E.N.
Abstract
Aim. The aim of the study was to estimate the susceptibility of baroreceptors in patients following different types of surgical correction of aortal arch hypoplasia. Materials and methods. The results of surgical treatment were assessed in 52 patients, who underwent surgical treatment for aortal coarctation. The patients were divided into two groups according to the technique for defect correction: reconstruction using modified reverse plasty LPA (group I, 26 persons) and reconstruction by means of “extended” anastomosis (group II, 26 persons). Results. The postoperative follow-up period was 25 (21; 30) months. Spontaneous susceptibility of receptors was noted between the groups and was reliably higher in group II - 11,6 (10,5; 12,6) versus 9,1 (8,2; 10,1) in group I, p - 0,04. Pulse blood circulation was also higher in group II - 7,7 (5,8; 9) (m/c)-1 versus 6,5 (5,4; 7,1) (m/c)-1 in group I and differed between the groups, p - 0,04. Conclusions. Reduced baroreceptor susceptibility in patients after the modified reverse plasty of the left clavicular artery permits to consider it the technique of choice for patients with coarctation and arch hypoplasia, as a method decreasing the occurrence rate of arterial hypertension in the remote postoperative period.
Perm Medical Journal. 2016;33(2):6-12
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CONTRIBUTION OF ATRIAL FIBRILLATION TO FORMATION OF CARDIORENAL CORRELATION IN HYPERTENSIVE PATIENTS
Lebedeva Y.I.
Abstract
Aim. The aim of the study was to evaluate the contribution of atrial fibrillation into development of chronic renal disease in patients with hypertension. Materials and methods. Eighty patients divided into 3 groups were examined. Group 1 included patients with sinus cardiac rhythm ( n = 30), group 2 - patients with persisting form of atrial fibrillation ( n = 30), and group 3 - patients with constant one ( n = 20). Results. Presence of atrial fibrillation was revealed to contribute to development of chronic renal disease. Decrease in glomerular filtration rate progresses when a patient is moving (by the stages of natural atrial fibrillation course) and correlates with patient’s age, left atrium size and cardiac output fraction. Conclusions. Patients with atrial fibrillation should be considered as patients with a threat of development of chronic renal disease.
Perm Medical Journal. 2016;33(2):13-16
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ROLE OF FIBROUS MYOCARDIAL DISORGANIZATION IN FORMATION OF RHYTHM DISTURBANCE IN PREMATURE VENTRICULAR EXCITATION SYNDROMES
Tuev A.V., Vasilets L.M., Khlynova O.V., Krivaya А.А., Shumovich I.V., Parshakova O.A.
Abstract
Aim. The aim of the study was to assess the markers of synthesis and degradation of collagen, the parameters of structural-functional status of myocardium in patients with Wolff-Parkinson-White (WPW) syndrome and phenomenon, as well as idiopathic atrial fibrillation (AF) and to evaluate their predictor value in the development of tachyarrythmias. Materials and methods. Seventy three patients were examined. The main group included 43 patients with premature ventricular excitation syndromes (16 with WPW phenomenon and 27 with WPW syndrome, mean age 25 ± 9,15 years, 29 (67 %) men and 14 (33 %) women). The comparison group joined 30 patients with “idiopathic” AF (mean age 28,8 ± 4,25 years, 67 % of men and 33 % of women) and practically healthy persons of the same age. To assess disturbance of fibrous matrix of the myocardium, quantitative value of tissue inhibitor of metalloproteinase-1 (TIMP-1), matrix metalloproteinase-9 (MMP-9) and carboxyterminal propeptide (PIP) - blood serum type I procollagen was studied. Structural-functional status of myocardium was investigated with echocardiographic method. Results. The study indicated participation of matrix metalloproteinases and their inhibitors in formation of structural-functional changes in the myocardium among WPW syndrome and phenomenon patients, with maximum dysbalance of type I collagen exchange registered in patients suffering from WPW syndrome combined with AF. When carrying out statistical processing, reliable difference between the indices of extracellular matrix status depending on WPW syndrome and phenomenon, as well as on the presence or absence of AF paroxysms against he background of ventricular preexcitation syndrome were found out. Conclusions. Presence of dysbalance of the fibrosis seromarkers, which correlate with geometry of the left atrium and have a predictor value for the development of atrial fibrillation with WPW, was stated.
Perm Medical Journal. 2016;33(2):17-22
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VEGETATIVE DISORDERS IN ADOLESCENTS WITH DIFFERENT TYPES OF HEADACHES
Semenova E.V.
Abstract
Aim. The aim of the study was to investigate the status of vegetative nervous system in adolescents with different types of headaches. Materials and methods. Ninety seven adolescents suffering from headache during the interictal period were examined. To assess the status of segmental and suprasegmental structures, the induced cutaneous sympathetic potentials were carried out. Results. Adolescents with cervicogenic headaches experienced increase in indices of the latent period as compared with healthy adolescents and patients suffering from tension headache and migraine. Significant growth in indices of the latent period of the induced potential in patients with cervicogenic headaches was established. Reliable reduction in the first phase amplitude in the group of female adolescents with cervicogenic headache was revealed. Significant rise in duration of the first phase of the induced potential from the girls’ left arms in this group was found. Duration of the ascending part of the second phase in female adolescents with migraine increased. Conclusions. Parasympathotonia is developing in adolescents with cervicogenic headaches, predominantly girls. Sympathotonia, prevailing in migraine, is proved by indices of duration of the ascending part of the second phase of the induced cutaneous sympathetic potential. Absence of statistically reliable differences when comparing the indices of duration of the ascending part of the second phase, duration of the descending part of the second phase and maximum amplitude in persons of different groups testifies in favour of the integrity of equilibrium position.
Perm Medical Journal. 2016;33(2):23-29
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COMPARATIVE CHARACTERISTIC OF QUALITY OF LIFE IN PATIENTS AFTER ATHEROTHROMBOTIC STROKE LOCALIZED IN CAROTID AND VERTEBROBASILAR POOLS
Kislitsyn Y.V., Konopatkina I.Y.
Abstract
Aim. The aim of the study was to compare the quality of life in patients after first-ever atherothrombotic stroke localized in the carotid and vertebrobasilar pools 10-14 months after the conducted therapy. Materials and methods. Examination of 124 patients with the strokes of carotid localization and 38 - of vertebrobasilar one was carried out. The quality of life was assessed with “SF-36 Health Status Survey” taking into account two parameters - mental health (MH) and physical health (PH). Results. It was established that in post-stroke patients, irrespective of localization of the damage, PH reduction significantly prevailed over MH level. During rehabilitation period, patients, who had suffered from ischemic stroke, demonstrated decreased parameters in physical sphere of the quality of life, whereas mental health was within the control parameters. Conclusions. Reduction of focal neurological deficit, which causes decrease in the level of patients’ physical health status, can be considered as a significant rehabilitation reserve.
Perm Medical Journal. 2016;33(2):30-33
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PERIOPERATIVE HEMODYNAMIC CHANGES IN PATIENTS WITH METABOLIC SYNDROME WHILE PERFORMING CHOLECYSTECTOMY FROM MINI-APPROACH
Ivanova I.V.
Abstract
Aim. The aim of the study was to ground an optimal variant of anesthetic management when performing cholecystectomy from mini-approach in patients with metabolic syndrome. Materials and methods. The results of studying hemodynamic indices in 90 patients during cholecystectomy from mini-approach in conditions of anesthetic management using “Isoflurane” or intravenous anesthesia on the basis of “Propofol” are presented in the paper. All patients underwent general clinical and special methods of investigation; in the perioperative period hemodynamic indices were monitored and additionally, the basic hemodynamic indices were estimated using calculated method. Results. It was detected while analyzing hemodynamics that in patients with metabolic syndrome, the initial systolic, diastolic and mean pressure was by 30 % higher versus the control group. The calculated indices such as stroke volume, circulatory minute volume, cardiac index were initially reduced (stroke volume - by 39 %, circulatory minute volume - by 37 %, cardiac index - by 44 %) in patients with metabolic syndrome as compared to the control group at all the stages of observation. Conclusions. Anesthetic management on the basis of “Propofol” changes to a lesser extent hemodynamic profile in patients with metabolic syndrome when performing cholecystectomy from mini-approach. Irrespective of the type of anesthetic management, maximum changes in hemodynamics are observed at the beginning of anesthesia in all patients with metabolic syndrome.
Perm Medical Journal. 2016;33(2):34-43
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GENDER PECULIARITIES OF LEPTIN, SOLUBLE LEPTIN RECEPTORS AND RESISTIN LEVELS IN PATIENTS SUFFERING FROM ARTERIAL HYPERTENSION ASSOCIATED WITH OBESITY
Shulkina S.G.
Abstract
Aim. At present, the problem of obesity as a risk factor for cardiovascular diseases remains actual. The aim of the work was to assess the gender peculiarities of the levels of adipokin and soluble leptin receptors in patients suffering from arterial hypertension (AH) associated with obesity. Materials and methods. The study enclosed 70 patients with AH. The parameters: mean body mass index (BMI) - 38,0 ± 9 kg/m2, mean age - 48,2 ± 2,4 years. There were 40 patients with obesity without AH and metabolic disorders and 30 practically healthy persons comparable by sex and age. Results. Leptin and resistin levels were reliably higher, but soluble leptin receptor concentration was lower in the group of AH patients with obesity. In the group of women, higher concentrations of leptin and resistin, and lower concentrations of soluble leptin receptors were observed than in the group of men. Correlation analysis indicated direct correlation of leptin and resistin with BMI, HOMA and TH indices, DAP level and reverse correlation of soluble leptin receptors with HOMA index. Conclusions. Thus, hormonal status of adipose tissue in women suffering from AH associated with obesity is characterized by higher leptin and resistin levels than in men. The cause of leptin resistance can be a low level of soluble leptin receptors.
Perm Medical Journal. 2016;33(2):44-49
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CLINICOECHOGRAPHIC CHARACTERISTIC OF TESTICLE ABSCESS
Prokhorov A.V.
Abstract
Aim. The aim of the study was to investigate the peculiar features of clinicoechographic picture of the testicle abscess. Materials and methods. The work is based on retrospective analysis of 10 testicle abscess cases observed over the period of 2005-2015. Standard clinicolaboratory studies and high resolution ultrasonography were applied. Results. Among acute inflammatory diseases of the testicle and appendage, the incidence of testicle abscess was 1 %. In 4/5 of cases, testicle abscess occurred as a complication of acute epididymoorchitis among patients over fifty with burdened immunodeficient background and different inflammatory urogenital diseases. According to ultrasonography data, testicle abscess at its acute stage was detected in 1 patient, subacute - in 2, chronic - in 7. The testicle abscess sizes were 28,4 (12-65) mm or 2,6 (1,3-5,5) cm3. Abscess occupied one segment of the testicle in 1 patient, two segments - in 5, total purulent melting of the testicle - in 4. By their acoustic signs, testicle abscess did not differ from those of the other localization. In its clinical course, testicle abscess at the acute and subacute stages was manifested as acute inflammatory disease of the testicle or appendage, at the chronic stage - as abscess and scrotal purulent fistula. As a result of clinicolaboratory study, testicle abscess was supposed in 4 patients, as a result of ultrasound study - testicle abscess was diagnosed in all patients. Pathomorphological study performed in 8 patients following orchiectomy indicated verification of testicle abscess in all of them. At the same time, in 1 case abscess was combined with testicle cancer, not revealed during the preoperative examination. Conclusions. Patients with acute inflammatory testicle and appendage diseases burdened by immunodeficient background (age over 50) have an increased risk for the development of testicle abscess and should be taken under a strict dynamic clinicolaboratory and echographic control in the course of mana-gement.
Perm Medical Journal. 2016;33(2):50-61
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OZONOTHERAPY EFFICIENCY IN CHILDREN WITH ATOPIC DERMATITIS AND ASSOCIATED ALLERGIC RHINITIS
Illek Y.Y., Zaitseva G.A., Galanina A.V., Chaganov I.B., Leushina N.P., Mischenko I.Y., Tarasov E.Y.
Abstract
Aim. The aim of the study was to investigate the clinical, immunomodulating and antirelapsing effects of ozonotherapy in children of preschool and primary school age suffering from atopic dermatitis associated with allergic rhinitis. Materials and methods. Sixty children aged 5-10, who suffered from disseminated moderate atopic dermatitis associated with persisting moderate allergic rhinitis, were under observation. They were divided into 2 groups depending on the conducted therapy. Group 1 ( n = 30) received complex generally accepted therapy, group 2 ( n = 30) - complex therapy combined with ozonotherapy. Patients suffering from atopic dermatitis associated with allergic rhinitis experienced studying of general clinical analyses and immunological reactivity indices. Results. Patients with atopic dermatitis and associated allergic rhinitis, who received complex therapy combined with ozonotherapy, as compared with patients receiving complex generally accepted therapy had longer clinical remission and normalized parameters of immunological reactivity. Conclusions. The results obtained while carrying out our own clinical observations prove high clinical, immunomodulating and antirelapsing effects of patients' complex management combined with ozonotherapy.
Perm Medical Journal. 2016;33(2):62-70
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EFFICIENCY OF DENTIN CARIES THERAPY USING DRUG WITH REMINERALIZING EFFECT
Leonova L.E., Pavlova G.A., Pershina R.G., Golovanenko A.L., Berezina E.S., Alekseeva I.V.
Abstract
Aim. The aim of the study was to carry out clinicoelectrometric assessment of the efficiency of using remineralizing gel when treating dentin caries. Materials and methods. Complex dental study included 135 patients aged 21 to 37 years (56 men and 79 women). Dental caries prevalence and severity indices and oral hygiene status were studied; pulp status was estimated by excitability index; mineralization degree of dentin of the pulp floor was studied using dentin electric conductivity (DEC) data with the unit “Dentest” (Geosoft Firm). Dental roentgenological investigation was performed with visiograph (Planmeca Firm). Results. Successful treatment of dentin caries requires active remineralizing therapy. As a result of preliminary biopharmaceutical, technological and clinical studies, the composition of gel for dentin remineralization was offered; technology of its preparation was developed; standardization was fulfilled according to authenticity and quantitative content of the basic reactants, technological parameters and microbiological purity. By means of the offered drug, a complex problem including simultaneous presence of calcium, phosphorus and fluorine ions is solved. Remineralizing gel used at the first stage of deep caries treatment contributes to intensive mineralization of dentin and permits to fill carious cavities without therapeutic basis. Conclusions. The studies on the use of remineralizing gel for treatment of dentin caries make it possible to recommend it as an effective remineralizing remedy at the initial stage of dentin caries therapy.
Perm Medical Journal. 2016;33(2):71-75
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WAYS FOR RAISING EFFICIENCY OF SHORTENED COMBINED COURSES OF SULFIDE BALNEOPELOTHERAPY OF HYPERTENSION AT HEALTH-RESORT
Petukhova I.V., Vladimirsky E.V., Rybolovlev E.V.
Abstract
Aim. The aim of the study was to investigate the possibility of applying the shortened courses of health-resort treatment using sulfide balneopelotherapy during 14 days and the local influence of low-frequency variable magnetic field on biologically active points according to E.V. Rybolovlev method. Materials and methods. One hundred and twenty patients with stage I and II arterial hypertension (AH) were examined. The study joined patients aged 30-65 years including 62 women and 58 men. Therapeutic complexes for hypertensive patients lasting for 21 days and 14-day courses of sulfide balneopelotherapy alone and combined with magnetotherapy were studied and compared. Results. In all the groups, patients subjected to daily measurement of office AP had hypotensive effect. When studying endothelial dysfunction, more marked vasodilating effect was registered during a 22-day course of balneopelotherapy (group 1). Shortening of balneopelotherapy course (group 2), leads to reduction of vasodilating effect. In group 3 (combination of a 14-day therapy with magnethotherapy), increase in endothelium-dependent vasodilation was revealed. Conclusions. Shortening of sulfide balneopelotherapy course from 21days to 14 days resulted in reduction of hypotensive effect. Combination of a 14-day therapeutic complex with local magnetotherapy leads to rise in hypotensive effect. This complex approaches by its efficiency a 21-day balneopelotherapy course for treatment of hypertension.
Perm Medical Journal. 2016;33(2):76-81
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ASSESSMENT OF CORRECTING ARGININE AND CARNITINE EFFECTS ON ACTIVITY AND DISTRIBUTION OF SKELETAL AND SMOOTH MUSCLE L, H CATHEPSINS IN MARKED HYPERHOMOCYSTEINEMIA
Ilyicheva A.S., Fomina M.A., Isakov S.A.
Abstract
Aim. The aim of the study was to investigate the activity of L, H cathepsins with assessment of changes in permeability of lysosomal membranes of the rat tibial muscle and thoracic aorta wall in conditions of experimental marked hyperhomocysteinemia when introducing L-arginine and carnitine. Materials and methods. Ninety six homogenized samples of muscular tissues (48 tibial muscle samples and 48 thoracic aorta wall samples) from white convectional Wistar male rats served as a material to be studied. Modelling of severe hyperhomocysteinemia was realized by means of a daily intragastric introduction of methionine suspension twice a day. In experimental and control groups, arginine and carnitine were introduced with a six-hour interval from introduction of the corresponding suspension. Results. Blood serum homocystein content in animals receiving methionine (hyperhomocysteinemia modeling) statistically significantly increased versus the corresponding control group (293,10 [273,10; 318,20] and 5,90 [5,50; 6,70] mcmol/l). In the samples of animals receiving L-arginine and carnitine against the background of methionine, homocysteine concentration significantly decreased versus the animals with hyperhomocysteinemia, but did not reach the control group values. Marked hyperhomocysteinemia is accompanied by growth of activity of skeletal and smooth muscle L, H cathepsins, development of lysosomal membrane permeability. Conclusions. Arginine reduces cathepsin H and acid phosphatase activity, has a stabilizing effect on lysosomal membrane in the skeletal muscle and decreases cathepsin L activity with no stabilizing effect on lysosomal membranes in the smooth musculature. Carnitine reduces cathepsin L activity and has a stabilizing effect on lysosomal membrane of the muscular tissues studied.
Perm Medical Journal. 2016;33(2):82-89
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ERYTHROPOIESIS IN ERYTHROBLASTIC BONE MARROW ISLETS DURING TOXIGENIC PERIOD AFTER EXPOSURE TO DIFFERENT POLYCHLORINATED BIPHENYLS DOSES
Kayumova A.F., Gabdulkhakova I.R., Bogdanova A.V., Fazlyakhmetova M.Y., Samokhodova O.V., Shamratova A.R.
Abstract
Aim. The aim of the study was to investigate the status of erythron in toxigenic period after the subacute exposure to polychlorinated biphenyls (PChB) with calculation of the absolute quantity and distribution of erythroblastic islets of the rat femur bone marrow by maturity classes. Materials and methods. The model of subacute PChB intoxication was created by introducing the commercial mixture “Sovol” to rats in the volume of 1 ml daily during 28 days using intragastric pump. According to the introduced dose of the preparation, animals were divided into 2 groups: group I (1/2 LD50) - the total dose of PChb for all the period of its introduction was 3000 mg/kg; group II (1/40 LD50) - the total dose of PChB for all the period of its introduction was 150 mg/kg. Vegetable oil in the dose of 1 ml was introduced to the animals of the control group during 28 days, as well. The experimental material was sampled at the days 7, 28, 56 after the completion of the period of subacute PChB intoxication (28 days) for each group of animals including the control. To assess the status of hemostasis in the central component of erythron, the absolute number was calculate and erythroblastic islets (EI) of the femur bone marrow were distributed by maturity classes using Yu.M. Zakharov, I.Yu. Melnikov, A.G. Rassokhin method (1984-1990); functional indices of EI erythropoiesis were estimated with L.V. Vorgovaya and Yu.M. Zakharov method (1990). Results. It was established, as a result of the conducted studies, that in the groups of rats, introduced PChb in the dose of 1/2 and 1/40 LD50, stress reaction in the system of erythropoiesis was observed. Just after the completion of PChB introduction, during two months there occurred an intensive reconstruction of red blood with activation of compensating erythropoiesis Conclusions. The results confirm the damaging effect of different PChB doses that requires constant control of blood in subjects permanently contacting with dioxin-like compounds at production.
Perm Medical Journal. 2016;33(2):90-97
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PECULIARITIES OF EARLY PROCESS COURSE IN RATS AGAINST THE BACKGROUND OF ALLOXAN DIABETES WHEN USING DIFFERENT METHODS OF LOCAL THERAPY
Studenikin A.V., Stadnikov A.A., Nuzova O.B., Kolosova N.I.
Abstract
Aim. The aim of the study was to determine the clinical efficiency of local use of “Miliacyl” and EHF-therapy for the treatment of purulent wounds against the background of alloxan diabetes in experimental conditions. Materials and methods. One hundred and forty white outbred rats were studied. In the main group, miliacyl and EHF-therapy were used for the treatment of purulent wounds. In the control group I no therapy of wounds was carried out; in the control group II “Miliacyl” was used; EHF-therapy was applied in 24 rats of the control group III. Results. In experimental animals, damage of pancreatic islet cells during the early period of observation was reflected in different types of structural changes, predominantly of the degenerative type. Comparative study of tissue structures of purulent wounds in different conditions showed a high therapeutic efficiency of combined use of “Miliacyl” and EHF-therapy. Strengthening of leukocytic and macrophagal reactions, faster arrest of inflammatory process and separation of necrotic masses was revealed. Conclusions. Potentiation phenomenon of anti-inflammatory and regenerator effect when using miliacyl and EHF was stated.
Perm Medical Journal. 2016;33(2):98-103
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PECULIARITIES OF PHYSICAL DEVELOPMENT AND FUNCTIONAL STATUS IN YOUNG ATHLETES GOING IN FOR CYCLIC AND PLAYING KINDS OF SPORT
Chainikov P.N.
Abstract
Aim. The aim of the study was to estimate the peculiar features of physical development and functional status in young basketball-players and swimmers. Materials and methods. The study enclosed 24 basketball-players and 28 swimmers of 2001 year of birth: males aged 14, sports grade - not higher than adult grade I. Physical development included measurement of morphological and functional parameters (weight, height, chest circumference at rest, at exhalation, at inhalation, spirometry, dynamometry of the right and left hands). Diagnosis of functional status included the following: heart rhythm variability, assessment of tension of regulatory systems of the body according to R.M. Bayevsky method, 20-curtsey test, calculation of reaction quality indices, Stange’s tests, determination of physical capacity for work and calculation of maximum oxygen demand using indirect method. Results. Basket-ball players aged 14 as compared with the swimmers of the same age had greater parameters of height, heart rate at rest and lower indices of right hand dynamometry and lung capacity. The maximum oxygen demand value was reliably higher in athletes-swimmers being extremely high in 64,2% of cases, high - in 10,7 %, medium - in 10,7 %. Conclusions. The resulting data indicate a high level of physical development and functional status in athletes going in for cyclic and playing kinds of sport. The obtained results characterize from different aspects the peculiarities of physical development and functional status in male athletes going in for cyclic and playing kinds of sport.
Perm Medical Journal. 2016;33(2):104-111
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ASSOCIATION OF SALIVARY CORTISOL LEVEL WITH ADIPOPEXIS IN HEALTHY YOUNG ADULTS
Kozlov A.I., Vershubskaya G.G., Manukyan A.S., Negasheva M.A.
Abstract
Aim. The aim of the study was to analyze the association of somatic indices with salivary cortisol (SC) level in healthy young adults. Materials and methods. Examination of 154 healthy students aged 20-23 years (102 women, 52 men) was conducted. Anthropometric study included the measurement of the body length and mass, waist and femur circumferences. Salivary cortisol content was determined using immunoenzyme method. Results. Salivary cortisol level in the examined persons (4,87 nmol/l) was reduced, but did not exceed the standard variation limits. No significant associations of SC content with the body length and mass and mass-height indices were revealed. The waist circumference to femur circumference ratio correlated with salivary cortisol level in men ( Rsp = -0,29; p = 0,036), but not in women. Conclusions. The results agree with the data of publications and confirm the hypothesis that cortisol production is associated with healthy human somatic characteristics.
Perm Medical Journal. 2016;33(2):112-117
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EXPRESS METHODS FOR ASSESSMENT OF HEALTH STATUS IN STUDENTS OF HIGHER SCHOOLS
Mozgovaya L.A., Rochev V.P., Fokina N.B., Sivak E.Y., Zadorina I.I., Paklin R.V., Birina O.S.
Abstract
Aim. The aim of the study was to investigate the correlation between the salivary humoral immunity factors and the number of complaints reflecting the functions of central nervous and cardiovascular systems in students of higher schools. Materials and methods. The study enclosed 36 students of the fourth course of Chemical Faculty of Perm State National Scientific Research University. It was aimed at assess of students’ health status using a new express method developed by collaborators, which is based on the determination of humoral factors of immunity in the human saliva. Results. A mean value of salivary antibody titer equal to 16-64 is optimal for students’ health status; as this index increases, the number of complaints is growing. Conclusions. The obtained results make it possible to recommend a safe express method for assessment of students’ health status.
Perm Medical Journal. 2016;33(2):118-124
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NA PUTI K ZDOROV'Yu I KRASOTE
El'kin V.D., Sedova T.G., Kuznetsov I.D., Novoselova M.Y., Kopytova E.A.
Abstract
К 95-летию кафедры дерматовенерологии Пермского государственного медицинского университета
Perm Medical Journal. 2016;33(2):125-128
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