Vol 39, No 1 (2022)

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Full Issue

Original studies

Pattern and features of mental changes in dermatological and gastroenterological patients

Elkin V.D., Kobernik M.Y., Sedova T.G., Borodina E.N., Andrusenko A.A.

Abstract

Objective. To conduct a comparative analysis of mental disorders in dermatological and gastroenterological patients.

Materials and methods. The study involved 84 persons who formed two groups: group I included 42 patients with dermatoses without concomitant diseases of internal organs; group II consisted of 42 gastroenterological patients without a history of skin pathology. The groups were comparable by age, gender and social status; all were residents of Perm. The examination, in addition to general clinical and standard laboratory techniques, included a psychological study using special scales to determine personal characteristics, cognitive functions, and emotional disorders. Methods of parametric and nonparametric statistics were used to account for and analyze the results.

Results. Mental changes were found in the majority of dermatological and gastroenterological patients, mainly emotional disorders were observed. According to the indications of the hospital anxiety and depression scale HADS, Hamilton scale, Tsung self-assessment scale, anxiety was more often detected in dermatological patients, and depression – in gastroenterological patients.

Conclusions. The majority of dermatological and gastroenterological patients have mental disorders, which are characterized by disorders of the emotional sphere. A significant difference was revealed in the structure of emotional disorders in dermatological and gastroenterological patients: anxiety was mainly determined in dermatological patients, and depressive symptoms prevailed in gastroenterological patients. The data obtained will help to use a comprehensive approach to the treatment of comorbid mental disorders, which will improve the quality of medical care.

Perm Medical Journal. 2022;39(1):5-10
pages 5-10 views

Pathogenetic associations of indicators of prenatal screening of the firsr trimester of pregnancy with fetal growth retardation

Dektyarev A.A., Kudryavtseva E.V., Kovalev V.V.

Abstract

Objective. To determine the relationship between the indicators of prenatal screening of the 1st trimester and the intrauterine growth retardation (IUGR).

Materials and methods. A prospective cohort study was carried out. Group 1 included 75 patients with fetal intrauterine growth retardation, group 2 – 414 women who gave birth to a live, full-term healthy baby with normal weight and height parameters. In all patients, the anamnestic parameters, indicators of PAPP-A, b-hCG, PlGF, thickness of the collar space and the pulsation index of the uterine arteries (PI UA) were compared.

Results. A number of significant differences in the anamnestic parameters were found between the groups. In group 1, multiparous women were met more often (16 % compared with 2.9% in group 2, p<0.001), women after сesarean section (13.3% and 5.6%, respectively, p=0.013), women with a history of spontaneous and artificial abortions (46.7% and 34.1 %, p=0.036). In addition, in group 1, patients were more likely to have uterine myoma – in 9.3 % versus 3.4% in group 2 (p=0.019). In group 1, during the first trimester screening, PAPP-A values ​​were lower – 1.238 (0.68–2.05) IU/ml versus 2.25 (1.28–3.9) IU/ml in group 2 (p<0.001), and PlGF – 13.73 (10.22–19.09) IU/ml versus 17.19 (12.1–25.38) in group 2 (p=0.002). There were no significant differences in the level of b-hCG. The average pulsation index of the uterine arteries, on the contrary, in group 1 in the first trimester was higher than in group 2 – 1.73 (1.42–2.11) and 1.55 (1.32–1.85), respectively (p=0.024).

Conclusions. Thus, a number of anamnestic data and screening indicators for the first trimester have a statistically significant relationship with the presence of IUGR of the fetus; therefore, these indicators can be used to assess the risk of this pregnancy complication.

Perm Medical Journal. 2022;39(1):11-20
pages 11-20 views

Cellular composition of gastric glands in chronic gastritis among children

Akkuratova-Maksimova I.S., Manyakina O.M., Shkolina O.V.

Abstract

Objective. To establish the features of the cellular composition of gastric mucosa glands in chronic Hp-associated gastritis among children to improve its diagnostics.

Material and methods. Morphometric analysis of fundal and pyloric gland cell populations was performed in 214 children aged 6–15 years with Hp-associated chronic gastritis. For this purpose, the number of main, parietal, endocrine and additional cells was calculated in the materials of gastrobiopsy of the gastric mucosa, the result was expressed in ‰ (per 1000 epithelial cells).

Results. It was found that as the severity of inflammation in the fundal glands increases, the number of main cells decreases, the number of parietal, accessory and especially endocrine cells grows. In the pyloric glands, a reduction of the parietal pool, a decrease in the population of additional cells and a sharp increase in endocrinocytes is registered. With a decrease in the severity of inflammation, positive changes in the cellular composition of the glands are observed, but its full normalization does not occur 6 months after the course of antihelicobacter therapy. A significant proportion of patients, shows morphological signs of gastric mucosa atrophy, which is associated with inflammation and is uncertain. Its presence does not significantly affect the cellular composition of the gastric glands, and the regression of the inflammatory process is accompanied by a decrease in the degree of atrophy or complete disappearance of signs of the latter.

Conclusions. The addition of a standard study of gastrobioptates with a quantitative morphometric analysis of the cellular composition of the fundal and pyloric glands in chronic gastritis among children objectifies the data of morphological assessment of pathohistological picture of gastric mucosa.

Perm Medical Journal. 2022;39(1):21-26
pages 21-26 views

Integral leukocgram indices in children with coronavirus infection COVID-19

Korotaeva K.S., Furman E.G., Sumlivaya O.N.

Abstract

Objective. To study the changes in hematological leukocyte indices among children with coronavirus infection COVID-19 in the dynamics of infectious process.

Materials and methods. The work is based on the analysis of clinical and laboratory data from 91 pediatric patients with COVID-19. On the basis of a general blood test, the following hematological leukocyte indices were determined: the entropy degree of leukogram according to A.V. Gorelov et al.; leukocyte intoxication index according to V.K. Ostrovsky; nuclear endotoxicosis degree index according to G.D. Dashtayants; Harkavi adaptation index; Krebs index; leukocyte index; neutrophils to monocytes ratio index; lymphocytes to monocytes ratio index.

Results. The most sensitive hematological indices were the entropy degree of leukogram according to A.V. Gorelov et al., indicating a violation of the dynamic constancy of leukogram; neutrophils to monocytes ratio indices, lymphocytes to monocytes ratio indices, showing the presence of a viral infection. At the peak of the infectious process, C-reactive blood protein index significantly correlated with the endotoxicosis index according to G.D. Dashtayants (R = –0.271; p≤0.05), with neutrophils to monocytes ratio index (R = 0.276; p≤0.05); and in the period of early convalescence - with leukocyte intoxication index according to V.K. Ostrovsky (R = 0.743; p≤0.05), with endotoxicosis indices according to Dashtayants (R = –0.785; p≤0.05) and neutrophils to monocytes ratio index (R = 0.743; p≤0.05).

Conclusions. The calculation of hematological leukocyte indices increases the information capability of the general blood test in children with coronavirus infection COVID-19, provides important additional information on intoxication syndrome, the state of immune response, the persistence of inflammatory process during the period of convalescence as well.

Perm Medical Journal. 2022;39(1):27-34
pages 27-34 views

Body dysmorphic disorder: some diagnostic approaches

Khramtsova N.I., Plaksin S.A., Zayakin Y.Y., Glushenkov A.S., Fadeeva M.V., Sotskov A.Y., Ponomarev D.N.

Abstract

Objective. Dysmorphophobis (body dysmorphic disorder, BDD) is a mental disorder characterized by excessive preoccupation with any imaginary or mild physical defect that causes significant discomfort, distress in the social sphere and other important areas of human activity.

The aim was to analyze the possibilities of foreign validated methods for detecting body dysmorphic disorder in a Russian-speaking audience.

Materials and methods. Two questionnaires have been translated into Russian, BDDQ-DV and DCQ. The survey was carried out in three samples: patients of a somatic hospital (55 women), clients of a plastic surgeon (71 women) and senior students of the Perm State Medical University (31 women).

Results. A positive answer to the question about the presence of a “defect” in appearance was given by the majority of the survey participants. Most of them described in detail those “defects” of their appearance that bother them. More than half of them think a lot about the defects. A question with a request to describe the "defect" allows the doctor to clarify the indications for its correction. If the medical correction is not indicated, the physician of the somatic profile can refer the patient for psychological correction. Answers regarding the severity of feelings about the “defect”, about disorders in social and professional life, about how long it takes to think about a “defect” and attempts to hide it, as well as whether the respondents have previously consulted about it with a doctor, and what were the results of consultation, allow us to suspect the presence of BDD and refer the respondent to a profile specialist. The analysis of internal consistency demonstrated the possibility of using these questionnaires in scientific research (Cronbach's alpha 0.82–0.84).

Conclusions The presented Russian-language versions of the DCQ and BDDQ-DV questionnaires can be recommended for scientific research as a screening tool for detecting body dysmorphic disorder among females of different age groups. However, their implementation in practice requires a deeper adaptation to the Russian-speaking audience.

Perm Medical Journal. 2022;39(1):35-46
pages 35-46 views

Genetic regulation of cytokine inflammation in oncohematological diseases

Loshkova E.V., Ponomarenko Y.B., Kondratieva E.I., Lebedev V.V., Kleschenko E.I.

Abstract

Objective. To analyze the correlations of the polymorphous variants of the genes – the modifiers of immune response (IL1-β/+3953, IL1RN*VNTR, TNFA*G-308A) with the development of oncohematological diseases (OHD) and the production of pro-and anti-inflammatory cytokines (IL-1β, IL-1Ra, TNF-α, INF-γ, IL-2, IL-4, IL-6, IL-8, IL-10, IL-18).

Materials and methods. The examination included 100 children (57 (57 %) boys и 43 (43 %) girls, with the mean age 7.50 (2.5–12.60 years) suffering from malignant blood diseases. The cytokine content (IL-1β, IL-4, IL-6, IL-8, IL-18, IL-1Ra и IL-10) was determined using IFA, the genetic typing of the genetic variants of the genes of cytokines IL1-β/+3953, IL1RN*VNTR, TNFA*G-308A – PCR and RFLP methods.

Results. In case of lethal outcome, 14% of cases, the TNF-α IL-6, IL-8, IL-18 INF-γ and IL-10 levels were reliably higher, compared with the survived patients. Renal function disorder detected among 13% of children was accompanied by an increase in IL-1β, IL-6, IL-8, IL-18, IL-1Ra and INF-γ compared to the patients without nephropathy and the control group (p<0.05). Eighteen OHD children with high concentration of IL-1β, IL-1Ra, IL-6, IL-8, IL-18 and INF-γ had fractures (р<0,05). Against the background of OHD, the carriage of the genotype А2А2 of the polymorphic variant VNTR IL1RN gene was observed 13 times more often, the carriage of the allele A2 – 2.16 times more often. The carriers of the genotype A2A2 of the genetic variant VNTR IL1RN gene had an increased risk of nephropathy by 20.89 times, the carriers of the allele A2 – 3.05 times more often. Children with OHD complicated by bacterial infection by 10.77 times more often had the genotype A2A2 and by 2.45 times more often – the allele A2 of the genetic variant VNTR IL1RN gene.

Conclusions. The carriers of the minor genotype A2A2 of the gene IL1RN*VNTR had a reliably higher production of the antiinflammatory IL-1β, IL-6, IL-8, IL-18 и IL-1Ra. The carriers of the genotype GA of the gene TNFA*G-308A had a significantly higher values of IL-1β, IL-18, IL-6, IL-8, TNF-α.

Perm Medical Journal. 2022;39(1):47-65
pages 47-65 views

Methods of diagnosis and technologies

Modification of emulsified fat (nanofat) obtaining procedures

Khramtsova N.I., Plaksin S.A., Gulyaeva N.I., Sotskov A.Y., Ponomarev D.N.

Abstract

Objective. To modify the procedure by reducing the number of filters and passages through them.

Materials and Methods. 16 samples of fat, aspirated by a syringe from the abdominal region were examined. Fat filtration was carried out through anaerobic fat transfers with an inner diameter of 1.4 mm and 1.2 mm, as well as an emulsifying filter (nanofat filter). The content of destroyed adipocytes and fibroblast-like cells was assessed.

Results. The 1.2 mm filter with 10 passages protocol provides determination of the minimal number of adipocytes while maintaining fibroblast-like cells. While filtrating through the 1.4 mm transfer, and then immediately through the “nanofat filter”, numerous connective tissue fibers with fibroblast-like cells are identified. When filtrating an adipose tissue using the 1.4 mm transfer 10 times, then – using “nanofat filter” 5 times, there was obtained a homogeneous fat emulsion with a high content of morphologically intact adipocytes, the particle diameter of which allows injecting with a thin needle syringe.

Conclusions. To obtain “nanofat”, it is possible to optimize the lipograft filtration protocol proposed by P. Tonnard (2013), depending on the purpose of using the obtained product.

Perm Medical Journal. 2022;39(1):66-73
pages 66-73 views

Prospects of mathematical modelling for optimization of intersystem bypass grafting in congenital heart diseases among children

Sinelnikov Y.S., Arutyunyan V.B., Porodikov A.A., Biyanov A.N., Pospelova N.S., Kuchumov A.G., Tuktamyshev B.S.

Abstract

Objective. To study the facilities of mathematical modelling of the system aorta-shunt-pulmonary artery for assessing the efficiency of shunt functioning.

Materials and methods. The risk factors for the development of complications in 35 newborns and infants of the first year of life were analyzed while carrying out the procedure of the modified Blalock-Taussig shunt (MBTShunt). The study lasted from 2016 to 2021. The age median at the time of operation was 10 (Q1–Q3: 3,5–30) days (from 1 to 180), the body mass median – 3,0 (Q1–Q3: 2,8–3,54) kg. The shunt size median was 3,5 mm (Q1–Q3: 3,5–3,5), and the median of shunt size per 1 kg of body mass – 1,11 (Q1–Q3: 1,0–1,21) mm/kg.

The shunt size was increased for 4 out of 35 (11.4%) patients. As a result of cooperation with Perm Polytechnic University, in the frameworks of the program of hydrodynamic modelling evaluation, the data from 4 patients were processed mathematically to assess blood flowing through the MBTShunt.

Results. Three (9 %) out of thirty five patients died in 3 (Q1–Q3: 2,5–11,0) (min–max 2–19) days because of cardiorespiratory decompensation. The only prognostically unfavorable risk factor for death was a large value of shunt size to body mass ratio (p=0.023). It was stated according to mathematical modelling data that the blood flow through the pulmonary arteries in all the analyzed types of shunts was not symmetric. An increase in the diameter of a shunt permits to improve a symmetry of blood flow through the left and right branches of the pulmonary artery.

Conclusions. The procedure of MBTShunt remains the procedure of high risk that is associated with a significant sickness rate and death rate in the early postoperative period. Mathematical modelling of the system aorta-shunt-pulmonary artery prior to the operation makes it possible to choose an optimal diameter of shunt and place of its implantation and will become one of the stages to personified surgery of congenital heart diseases in the future.

Perm Medical Journal. 2022;39(1):74-84
pages 74-84 views

Preventive and social medicine

Manifestations of epidemic process of tuberculosis among HIV-infected patients and dependence of infection frequency on immunodeficiency level and HIV viral load

Sergevnin V.I., Tukacheva O.V.

Abstract

Objective. To assess the manifestations of the epidemic process of tuberculosis (TB) in HIV-infected persons and the frequency of infection depending on the level of immunodeficiency and viral load.

Materials and methods. The epidemiological manifestations of TB incidence among HIV-infected and HIV-negative population of the Perm Region for 2014–2019 were studied. The frequency of TB in HIV-infected patients was determined depending on the level of immunodeficiency (96 patients) and viral load (61 patients).

Results. On average, the incidence of TB among HIV-infected persons was by 36 times higher than that of noninfected persons. Among those infected and noninfected with HIV, TB was registered significantly more often among adults, and mainly men. The incidence of TB among HIV-infected persons is higher among urban population, while HIV-negative – among rural residents. The incidence of TB in HIV-infected persons increases with an increase in the immunodeficiency and viral load.

Conclusions. Persons with HIV infection are at risk for TB. The incidence of TB in HIV-infected persons increases with an increase in immunodeficiency and viral load.

Perm Medical Journal. 2022;39(1):85-93
pages 85-93 views

Contamination of water bodies of Astrakhan region with helminth-protozoan infestations

Nikeshina T.V., Arakelyan R.S., Shendo G.L., Kovalenko A.V., Kiseleva A.A., Arakelyants O.A.

Abstract

Objective. To study and carry out the retrospective analysis of water contamination with helminth-protozoan infestations in Astrakhan Region for 2010-2019.

Materials and methods. During the analyzed period, 80962 samples taken from environmental objects were examined.

Results. The percentage of samples that did not meet sanitary and parasitological indicators was 1.2 % (951 samples). The proportion of water samples collected and examined for parasitological parameters (eggs and larvae of helminths, cysts of pathogenic intestinal protozoa and oocysts of cryptosporidia) was 7.5 % (6033 samples). Water samples were taken from various water sources: water from centralized water supply, water from swimming pools, water from open reservoirs, waste water, water from wells, and bottled water.

Conclusions. To conclude, the results were obtained indicating that the absence of positive findings in water samples from central water supply facilities indicates a high-quality filtration and prevention of these objects; the presence of cysts of dysentery amoeba and dead strongylid larvae in water samples, swimming pools, as well as the presence of eggs and larvae of helminths and cysts of pathogenic intestinal protozoa in open reservoirs, indicates fecal contamination of these objects; the presence of positive findings in samples of wastewater and water from wells shows that reliable deworming and disinfection of wastewater is not provided at these facilities.

Perm Medical Journal. 2022;39(1):94-103
pages 94-103 views

Assessment of life satisfaction and impact of work on personal life among heads of clinical departments

Yarotsky S.Y., Sandakov Y.P., Kochubey A.V., Kochubey V.V.

Abstract

Objective. To study life satisfaction and the impact of work on personal life among heads of clinical departments.

Materials and methods. A correspondence survey of 216 heads of clinical departments was conducted using standardized questionnaires with the calculation of the life satisfaction index and the indices of interaction between work and personal life. The average age of the respondents was 47.9 ± 8.08 years; the average length of service was 23.1 ± 8.60 years.

Results. The average life satisfaction index is 6.0 ± 0.951. There is a weak inverse correlation of the index with age r = –0.2; p = 0.004 and length of service r = –0.2; p = 0.001. The values of the life satisfaction index do not depend on gender (t = 0.23, p = 0.818), place of work (t = 0.14; p = 0.886), availability of qualification category (t = 0.36; p = 0.722), academic degree (t = 1.8; p = 0.073), second higher education (t = 1.67; p = 0.097), work in "red zone" (t˂0,001; p = 1,000). The average index of negative interference of work in personal life is 1.59 ± 0.474 and personal life in work is 1.04 ± 0.123, positive influence of work on personal life is 2.64 ± 0.897 and personal life on work is 3.35 ± 0.882. There is a significant difference in the index of negative interference of personal life in work by respondents of different sexes (t = 3.24; p = 0.001) who worked in hospitals (t = 3.14; p = 0.002) and in the "red zone" (t = –3.29; p = 0.01). There is a negative weak correlation between the life satisfaction index and the index of the positive impact of personal life on work (r = –0.34; p˂0,001) and work on personal life (r = –0.37; p˂0,001).

Conclusions. The life satisfaction index of department heads is high – 6.0 out of 7. However, a decrease in the ratings of the positive interaction of work and personal life with an increase in the satisfaction index dictates the need to continue research.

Perm Medical Journal. 2022;39(1):104-111
pages 104-111 views

Evaluation of quality and effectiveness of rendering medical care to patients with gonococcal infection in medical institutions

Rumyantseva M.A., Isaeva N.V.

Abstract

Objective. To assess the intensity of epidemic process in a long-term dynamics of gonorrhea sickness rate and evaluate the quality and effectiveness of rendering medical care to patients with this infection in medical institutions of Perm.

Materials and methods. In this work, the data of official statistics of the State Budgetary Institution of Public Healthcare “Perm Regional Clinical Dermatovenerological Dispensary” are presented: official statistical form 12 “Information on the number of diseases” as well as accounting forms accepted by the Ministry of Public Health of Perm Krai. Epidemiological, descriptive-evaluative and analytical studies of the type “case-control, sociological (questioning method) and statistical methods were used.

Results. A long-term dynamics of gonococcal infection morbidity among the population of Perm for 1990–2020 was characterized by a marked tendency to decrease, an average annual decrease rate was 7.5 %. Despite the tendency to decline, from 2018 to 2020, there was observed an activation of epidemic process of the gonococcal infection. The growth rate was 137.5 %. Based on special investigations, it was established that 55.4 % of patients addressed to private clinics, 44.6 % (p>0.05) – to state ones (SBIPH PK RCDVD). In general, 76.5 % of patients from state and private clinics remained uncontrolled from the side of medical services. Thus, in three thirds of the foci, an active search of the sources of the infectious agent was not carried out. While studying medical documentation of 666 foci, epidemic diagnostics was performed only in 166 (24.9 %), in 500 foci the infectious agent source was not detected and investigated. At the same time, out of 500 foci, in 340 (68.0 %) one sexual partner for each focus remained unexamined, in 125 (25.0 %) foci – two-three sexual partners, and in 35 (7.0 %) foci – more than three sexual partners.

Conclusions. Recent years have witnessed the activation of epidemiological process of gonococcal infection in Perm. The gonococcal infection morbidity 2.5 times exceeded the indicators in the country as a whole. Patients with gonococcal infection addressed to state and private clinics in 55.4 % and 44.6 % of cases, respectively. Three thirds of patients with gonorrhea receive medical care not in a full volume, and with bad quality. In the state institutions, such patients make 15 %, in private ones – 85 %.

Perm Medical Journal. 2022;39(1):112-118
pages 112-118 views

Clinical case

Features of diagnostics and treatment of thyrotoxicosis in patients with severe comorbid pathology: clinical case

Styazhkina S.N., Chernyadeva E.V., Karmanova V.V., Sazhina K.I., Korobeinikov V.I.

Abstract

Objective. To demonstrate the stages of diagnostics and successful treatment of thyrotoxicosis in a patient with severe comorbid pathology.

Materials and methods. A clinical case report of a patient with toxic goiter is presented.

Results. To specify the state of the thyroid gland, diagnostic and laboratory methods were applied: ultrasound examination (thyroid volume increased up to 182 cm2, isoechogenic nodule in the left lobe – up to 1 cm, thyroid vascularization increased), spiral computed tomography (picture of diffuse nodular goiter with partial retrosternal location of the left thyroid lobe), hormone studies, the results of which revealed thyrotoxicosis. Thyroidectomy was subsequently carried out. Both thyroid lobes with isthmus were removed step-by-step with technical difficulties and high bleeding of tissues. The patient was discharged in 10 days in a satisfactory state.

Conclusions. Thyrotoxicosis is certainly a complex surgical pathology, in which correct assessment of the diagnosis by instrumental, clinical and laboratory methods is required, as well as successful surgical intervention. Not only normalization of hormonal status of a patient has to be taken into account, but also the possibility of disease relapse, contraindications due to age, physiological status, and comorbid abnormalities.

Perm Medical Journal. 2022;39(1):119-123
pages 119-123 views

Biology and experimental medicine

Modification of liver reparative regeneration in laboratory animals after partial hepatectomy

Maksimova A.Y., Valamina I.E., Polushina L.G., Tsvirenko S.V., Bazarnyi V.V.

Abstract

Objective. To investigate the effect of cytoflavin on the adaptive liver growth after partial hepatectomy (PH).

Materials and methods. An experimental study was conducted on 60 male white mice aged 7–8 months, weighing 24–31 g. All animals were divided into three groups: group 1 – intact mice; group 2 – operated control mice, who received saline NaCl instead of the drug; group 3 – the main group of animals, who underwent partial hepatectomy, after which they received сytoflavin. Partial hepatectomy was performed by Claudia Mitchell and Holger Willenbring technique (2008). The preparation cytoflavin (Russia) was injected intraperitoneally at a dose of 0.014 ml /10 g of body weight for 7 days once daily. Morphological and morphometric studies of hepatobiopsy specimens were conducted. Statistical analysis was carried out using the methods of nonparametric statistics.

Results. It was found that 3 days after PH, in the liver of animals of the main group, the number of dystrophically altered hepatocytes decreased by 25 times, the mitotic index increased against the background of the preserved radial-beam structure. There was an increase in the size of the cytoplasm and nucleus by 1.5 times relative to the intact group (p <0.05), that is associated with adaptive hypertrophy. At the same time, on the 3rd day, in the control group the number of dystrophically altered cells was several times higher than in the intact animals and was accompanied by an increase in the cytoplasm of hepatocytes as a result of vacuolar degeneration after PH.

Conclusions: The use of cytoflavin leads to an increase in the mitotic activity of the partially resected liver, while the level of binuclear cells decreases. The manifestations of hepatocyte dystrophy also decrease. Comparison of the dynamics of the morphometric parameters of hepatocytes in animals of the control group and those who received cytoflavin after PH suggests that the studied drug stimulates the recovery processes in the liver during induced regeneration.

Perm Medical Journal. 2022;39(1):124-132
pages 124-132 views

Anniversaries and information on events

Professor Nikolai Sergeevich Strelkov: the 70th anniversary of birth

Shubina Z.V.

Abstract

The article is dedicated to the 70th anniversary of the birth of Strelkov Nikolay Sergeevich - Russian scientist, Honored Doctor of the Russian Federation, Doctor of Medical Sciences, professor, pediatric surgeon, State Prize Laureate of the Udmurt Republic.

Perm Medical Journal. 2022;39(1):133-136
pages 133-136 views

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