Perm Medical Journal

The peer-review scientific and practical bimonthly medical journal.


  • Olga V. Khlynova, MD, Dr. Sci. (Medicine), Corresponding Member of the Russian Academy of Sciences (Wagner State Medical University). ORCID iD: 0000-0003-4860-0112 




The journal was founded in 1923 by Medical Society of Perm University (ISSN Key title: Permskiĭ medit︠s︡inskiĭ zhurnal). The journal publish original researches and reviews, case reports and short communications on the following science fields:

  • Obstetrics and Gynecology
  • Oncology, X-ray therapy
  • Surgery
  • Endocrinology
  • Pediatrics
  • Pulmonology
  • Epidemiology
  • Clinical laboratory diagnostic


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Current Issue

Vol 40, No 4 (2023)

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Full Issue

Original studies

Violation of vertical balance of the body in children with one-sided high riding trochanter
Nikityuk I.E., Bortulev P.I., Vissarionov S.V.

Objective. To study the postural balance disorders in children with a one-sided high riding trochanter, depending on the direction of displacement of the general center of pressure (COP) of the body in the frontal plane.

Material and methods. A two-platform stabilometric study of 16 patients aged 11 to 16 years (M ± m = 13.1 ± 0.76) with a one-sided high riding trochanter of the femur was conducted. The children were divided into two groups: group I – 6 patients with a shift of the general COP  towards the affected lower limb (33[19 – 42] mm), group II – 10 patients with a displacement of the general COP  towards the intact lower limb (17 [8–36] mm). The control group included 16 healthy children of the same age.

Results. Depending on the displacement of the general COP towards the affected or intact lower limb, different values and ratios of stabilometric parameters were observed in patients of both groups individually under each of the contralateral lower limbs. The most pronounced asymmetry of the indicators of the postural balance of the lower extremities compared with the norm was revealed in the second group of patients. Among them, the median difference of sagittal displacement of the COP between the contralateral limbs DY was 45 mm, while in patients of the first group, the median DY was 7 mm. The medians of angular velocities Ω between the lower extremities were correlated as 36 to 23 degrees/s in the second group compared with 27 to 29 degrees/s in the first. Also, in patients of the second group, the highest indicator of excessive quartile deviation of the angle of the direction of oscillations of the vector diagrams α on the affected lower limb was revealed – 62° compared with the intact 11°.

Conclusions. Significant asymmetry of postural balance indicators in patients of the second group may be due to compensatory reactions of the body to prevent gross destabilization of the entire postural control system, therefore, such an imbalance corresponds to an adequate postural strategy.

Perm Medical Journal. 2023;40(4):5-15
pages 5-15 views
Endogenous and exogenous risk factors for infection of premature new-borns with pathogens of purulent-septic infections
Sheozheva A.V., Sergevnin V.I., Markovich N.I.

Objective. To identify the endogenous and exogenous risk factors for infection with pathogens of purulent-septic infections (PSI) in premature newborns in an obstetric hospital according to the data of routine microbiological monitoring.

Materials and methods. A bacteriological examination of 220 newborns (169 premature and 51 full-term) in resuscitation and intensive care unit (RICU) of the perinatal center was conducted. The same children were sampled on the day of admission to the RICU and on the 4th day of treatment. Biomaterial from the mucous membranes of the pharynx, nose, conjunctiva and umbilical fold was investigated in each child. The total number of samples was 1760.

Results. The frequency of isolation of microorganisms from premature newborns increased from 32.9 to 95.3 per 100 samples by the 4th day. It was 1.7 times higher in premature newborns than in full-term newborns. A statistically significant increase in the frequency of the release of PSI pathogens in premature newborns was found. It depended on the type of somatic pathology (undifferentiated intrauterine infection, respiratory disorders syndrome, perinatal central nervous system damage, intranatal asphyxia) and medical procedures (umbilical vascular catheterization, artificial lung ventilation, inhalation therapy, probe feeding).

Conclusions. The increased risk of infection with PSI pathogens in premature newborns in the RICU of the perinatal center is due to endogenous and exogenous risk factors.

Perm Medical Journal. 2023;40(4):16-22
pages 16-22 views
Role of connective tissue dysplasia in pathogenesis of diverticular disease
Valinurov A.A., Chernyshova T.E., Styazhkina S.N.

Objectives. To conduct a comparative analysis of the role of connective tissue dysplasia in the development of diverticular disease.

Materials and methods. At the screening stage of a single-stage study, clinical, functional, and radiological predictors of connective tissue dysplasia with diagnosed diverticular disease were evaluated. At the second stage of the study, a colonoscopy was performed. The disease was diagnosed by the combination of phenotypic signs of dysmorphic genesis.

Results. At the first stage, in 82 % of cases patients were concerned about their asthenic syndrome. Thirty-two patients with confirmed connective tissue dysplasia underwent colonoscopy. Diverticular disease was diagnosed in 28 patients (89.6 %).

Conclusions. High comorbidity of patients is associated with genetically determined disorders of connective tissue metabolism, manifested by a high frequency of diverticular formation. With a large number of diagnosed phenes, we can predict a rapid progression of diverticular disease. The frequency and severity are due to changes in the mechanical properties of the connective tissue of the submucosal layer.

Perm Medical Journal. 2023;40(4):23-30
pages 23-30 views
Diagnostics of chronic obstructive pulmonary disease in primary health care
Isgandarova G.N., Hatamzade E.M.

Objective. To assess the hypodiagnostics of chronic obstructive pulmonary disease (COPD) and identify the possible factors associated with it.

Materials and methods. The selection of patients in the polyclinic was carried out during spontaneous routine or planned visits, as a result of which 122 patients with obstructive ventilation disorders were selected and invited for further examination. The control group consisted of 20 volunteers without COPD and other pulmonary and severe somatic diseases. The indicators such as gender, age, smoking factor, severity of COPD were analyzed. Spirometry was performed using a portable ultrasonic spirometer.

Results. The mean age of patients with COPD was 55.9 ± 4.4 years; men accounted for 59.0 %, women – 41.0 %. At the time of the study, smokers accounted for 57.4 %. The results of spirometry were obtained in 41.8 % of patients, 58.2 % of patients did not undergo spirometry. After spirometry, the severity of COPD was revalued: stage I was classified in 36.1 % of patients, stage II – in 32.0 %, stage III – in 6.5 % of patients. The diagnosis was revalued after spirometry in 25.4 % of cases. In the age group of 40-45 years, the chance to find the risk of developing COPD in the main group was 0.208; in the control group – 0.250 (p>0.05); in the group of 46-49 years: 0.326 and 0.333 (p>0.05); 50-55 years: 0.402 and 0.538 (p>0.05); 56-60 year olds: 0.419 and 0.250 (p>0.05), respectively. In patients aged 56-60, OR=1.674 (95 % CI 0.523-5.356, p<0.05). In the smokers group, OR=1.645 (95 % CI 0.636-4.260, p<0.05). The chance of finding a risk factor for smokers in the main group was 1.346, in the control group – 0.818 (p<0.05).

Conclusions. Identification of patients at risk is feasible in the practice of family medicine. The use of spirometry contributes to the early detection of undiagnosed COPD and correct classification of the degree of the disease.

Perm Medical Journal. 2023;40(4):31-40
pages 31-40 views
Cardiac rhythm disturbances in patients suffering from chronic heart failure with absence and presence of concomitant metabolic syndrome: evaluation of long-term effect of previous myocardial infarction and surgical revascularization
Kurbanova J.K.

Introduction. Heart rhythm disturbances often complicate the clinical course of chronic heart failure, especially when heart failure is combined with metabolic syndrome. The influence of different exogenous and endogenous factors on the formation and aggravation of existing cardiac rhythm disturbances in such patients is insufficiently studied, in particular, the influence of metabolic syndrome, previous myocardial infarction and surgical myocardial revascularization.

Objective. To conduct a comparative analysis of the detected heart rhythm abnormalities in patients with chronic heart failure with and without an associated metabolic syndrome and to estimate the role of previous myocardial infarction and surgical revascularization on the detection rate of cardiac rhythm abnormalities.

Material and methods. One hundred and twenty patients with functional class II-III chronic heart failure due to coronary heart disease including 90 (75.0 %) patients with signs of metabolic syndrome and 30 (25.0 %) patients without metabolic syndrome were examined. Anthropometric data (height, weight, body mass index, waist volume), clinical course, data of laboratory and instrumental methods of examination were assessed. Electrocardiography, echocardiography with determination of myocardial structural and functional parameters, Holter electrocardiogram monitoring, assessment of blood lipid profile were performed.

Results. The results of comparative analysis indicate a number of characteristic features of the clinical course of chronic heart failure with concomitant metabolic syndrome, expressed by  deterioration of both myocardial electrical stability, and structural and functional heart state. According to Holter monitoring data, there was detected a significant frequency of supraventricular and ventricular extrasystoles, atrial fibrillation of various types, combined forms of arrhythmias in patients with concomitant metabolic syndrome. Echocardiographic studies revealed a significant increase in the left ventricular wall thickness combined with decreased systole-diastolic size of the heart. According to the laboratory study, there was observed a significant deterioration of all blood plasma lipid profile parameters with an increase in the atherogenicity index among patients with concomitant metabolic syndrome. Four variables (presence of metabolic syndrome, previous myocardial infarction, previous aortocoronary bypass surgery and angioplasty with stenting of affected coronary arteries) were analyzed as the factors provoking the occurrence or progression of cardiac rhythm disturbances. Two independent factors associated with the occurrence of cardiac rhythm disturbances were identified: the presence of concomitant metabolic syndrome and previous myocardial infarction that led to the development of postinfarction cardiosclerosis. The factor associated with the reduction of cardiac rhythm disturbances in the long-term period was also determined: revascularization by aortocoronary bypass and/or angioplasty with stenting of the affected coronary vessels in patients with chronic heart failure associated with coronary artery disease.

Conclusions. There was identified the factor associated with the reduction of heart rhythm disturbances in the long-term period – revascularization by aortocoronary bypass and/or angioplasty with stenting of the affected coronary vessels in patients with chronic heart failure associated with coronary artery disease.

Perm Medical Journal. 2023;40(4):41-54
pages 41-54 views
Role of vagal regulatory mechanisms in ulcerogenesis of perforative pyloroduodenal ulcers
Podoluzhny V.I., Radionov I.A., Kokoulina J.A., Startsev A.B.

Objective. To evaluate the role of psychosomatic and psychosocial factors and alcohol in the mechanisms of ulcerogenesis of perforated pyloroduodenal ulcers.

Materials and methods.  The incidence and volume of treatment of patients with perforated pyloroduodenal ulcers in Kemerovo for 52 years were analyzed. Digestive activity of gastric juice was assessed in case of perforated duodenal ulcer.

Results. It has been established that an increase in the number of patients operated on with perforated pyloroduodenal ulcers correlates with the chronic psycho-emotional overexcitation affecting the vagal regulatory mechanisms of the ulcerogenesis of the perforated pyloroduodenal ulcers. There is no constant direct relationship between the amount of pure alcohol consumption in liters per one adult a year and the incidence rate of disease.

Conclusions. Psychosomatic and psychosocial factors through the vagal regulatory mechanisms increase the aggressiveness of gastric juice and lead to an imbalance between the mechanisms of aggression and the protection of the duodenal mucosa, and, along with alcohol consumption, play an important role in the ulcerogenesis of perforated pyloroduodenal ulcers. The psychogenic factor clearly affects the incidence rate.

Perm Medical Journal. 2023;40(4):55-61
pages 55-61 views

Review of literature

Role of oxidative stress in female reproductive system: literature review
Berezina D.A., Kudryavtseva E.V., Gavrilov I.V.

In this review, the literature data regarding the influence of oxidative stress (OS) on the female reproductive system and fertility are analyzed. Oxidative stress occurs as a result of balance disturbance in the system of the formation of free radicals and mechanisms of antioxidant defense. During the last decade, there have been conducted many studies, demonstrating interaction between the oxidative stress and the development of various pathological processes. The influence of the oxidative stresses on the state of female reproductive system and fertility is of special interest. When analyzing the available for today data regarding OS and its effect on the body, it is becomes evident that this process is very important in physiology and reproductive pathology, development of gynecological and obstetric pathologies and fertility. The significance of OS in the pathogenesis of reproductive disturbances should be taken into account when developing new therapeutic methods. This issue needs further discussion and studying.

Perm Medical Journal. 2023;40(4):62-72
pages 62-72 views
Some epidemiological aspects of infectious and inflammatory complications of cardiac surgery with sternal access: literature review
Kasatov A.V., Gorowitz E.S.

Literature data on the mechanisms of sternal wound infection during open-heart surgery with sternal access are discussed. The possibilities of both exo-and endogenous contamination of the surgical site by gram-positive and gram-negative bacteria of various species are emphasized. The increasing role of endogenous mechanisms of sternal wound colonization after cardiac surgery is noted. At the same time, translocation of bacteria from various biotopes of patients is possible. In this regard, the prevention of infectious and inflammatory complications is recommended to carry out adequate decontamination during patient preoperative preparation.

Perm Medical Journal. 2023;40(4):73-81
pages 73-81 views

Methods of diagnosis and technologies

Optimization of diagnostic approaches of destructive pancreatitis
Zurnadzhyants V.A., Kchibekov E.A., Gasanov K.G., Bondarev V.A., Saydulaev W.A., Bondarev A.V.

Objective. To improve the diagnostics of destructive pancreatitis based on the concentrations of fibrinogen degradation products and lysozyme in blood serum and peritoneal exudate.

Materials and methods. One hundred and two patients with acute pancreatitis were examined and the diagnostic significance of fibrinogen and lysozyme degradation products was assessed. The age of the patients ranged from 19 to 63 years. The patients were treated in surgical hospitals of the city of Astrakhan. Of them, 74 patients diagnosed an edematous form of acute pancreatitis, received conservative treatment, and 28 patients with destructive forms of pancreatitis were operated on. The reference values of the studied markers were evaluated in 39 healthy individuals (donors).

Results. In the blood serum of patients with destructive pancreatitis, the concentration of fibrinogen degradation products was 2.0 [0.68;13.2] mg/l, that is significantly higher than in the group of patients with edematous acute pancreatitis, as well as in the control group. After the surgery, in the peritoneal exudate of 28 operated patients with destructive pancreatitis, the concentrations of fibrinogen degradation products increased by 0.93 times compared to the group with edematous acute pancreatitis and by 3.1 times significantly higher than in the control group. There were no statistically significant differences in the concentrations of fibrinogen degradation products in the peritoneal exudate and in the blood serum of patients with destructive pancreatitis. The concentration of lysozyme in the blood serum of patients with destructive pancreatitis was 20 [5.0;46.5] mg/l, that is significantly higher than in the control group and in the edematous form of acute pancreatitis. After the surgery, the concentration of lysozyme in the peritoneal exudate was 2.5 times significantly higher in patients with destructive pancreatitis than in the control group. The average lysozyme concentration in the peritoneal exudate of patients with destructive pancreatitis exceeded the serum concentrations by 2.1 times in comparative equivalent.

Conclusions. Assessment of the levels of fibrinogen degradation products, lysozyme in the blood and exudate allows to diagnose the destruction of the pancreas, as well as to determine the correct treatment tactics.

Perm Medical Journal. 2023;40(4):82-91
pages 82-91 views
Results of treatment of patients with recurrent ischemic ventricular tachycardia using radiofrequency ablation method in Perm Krai
Azizov S.N., Khuziakhmetov R.D., Kozhenov A.T., Gordiychuk R.N.

Objective. To analyze the results of radiofrequency catheter ablation in patients with stable ventricular tachycardia (VT), which is one of the basic causes of mortality in patients with structural heart disease and the most common mechanism of circulatory arrest.

Materials and methods. The results of radiofrequency catheter ablation were retrospectively analyzed in 10 patients with structural cardiac pathology, who suffered from stable monomorphic ventricular tachycardia, refractory to drug therapy.

Results. The primary final point of the study was freedom from recurrence of monomorphic VT paroxysms.  In our study, freedom from recurrent monomorphic VT paroxysms after the conducted RFA in patients with structural cardiac pathology for an average follow-up period of 14.5 ± 6.3 months was 70 %.

Conclusions. The radiofrequency catheter ablation can be considered as an optimal method for the treatment of recurrent VT paroxysms at the background of noneffective drug therapy in patients with structural changes in the heart caused by old myocardial infarction in anamnesis. 

Perm Medical Journal. 2023;40(4):92-101
pages 92-101 views

Preventive and social medicine

Clinical and epidemiological aspects of ascariasis
Arakelyuan R.S., Malsagova A.B., Mogilina E.A., Kurbangalieva A.R., Vlasova E.V.

Objective. To study and characterize the incidence of ascariasis in the population of the Astrakhan Region for 2017–2021.

Materials and methods. The diagnosis of ascariasis was made on the basis of epidemiological anamnesis, clinical picture of the disease (complaints and symptoms) as well as laboratory examination of feces (coproovoscopic method) – detection of parasite eggs in the biological material of patients (feces).

Results. From 2017 to 2021, 91 cases of human infection with ascarids were registered in the Astrakhan region, of which the incidence rate among children was 54.9 % (50 persons). Ascariasis was registered directly in the city – 41.8 % (38 persons) and in the districts of the Astrakhan Region – 58.2 % (53 persons). Most of the patients – 86.8 % (79 persons) complained about the presence of certain symptoms of the disease: pain in the epigastric region – 87.3 % (children) and 59.5 % (adults), nausea – 73.4 % (58 persons) and hyporexia – 68.4 %. When addressing for medical aid, in addition to anamnesis of the disease, an epidemiological anamnesis was also clarified: 97.8 % (89 persons) did not observe the rules of personal hygiene – this group of patients ate unwashed fruit and/or berries – 83.1 % (74 persons), did not wash their hands before eating – 79.8 % (71 persons). Onychophagy was noted by 16.5 % (15 persons including 12 children). Geophagy occurred in 9.9 % (9 persons – all children). After diagnosing, all patients were prescribed drugs with pirantel – 91.2 % (83 persons) and albendazole – 8.8 % (8 persons).

Conclusions. Ascariasis is an urgent problem of domestic healthcare, especially for pediatricians. Ascariasis is widespread throughout the Astrakhan Region, being detected, to a greater extent, in residents of the districts of the Astrakhan Region, that can testify to the consumption of unwashed fruit or berries contaminated with ascarid eggs, as well as possible soil contamination. Typical complaints were pain in the epigastric region, nausea, vomiting, diarrhea, hyporexia. Presumably, the main cause of the ascarid disease in residents of the Astrakhan Region could be the use of untreated wastewater and its sediments as organic fertilizers in collective and farm enterprises, as well as in individual households.

Perm Medical Journal. 2023;40(4):102-110
pages 102-110 views
Formation of values of motherhood, paternity, responsible parenthood in the youth to preserve reproductive health
Teplyakova N.V., Lenkova T.A., Mikhalenko T.N., Solovieva M.S., Artemenkov A.A.

Objective. To transmit the experience of implementing the project of the Charitable Foundation "Road to Home" "Family is important!" in the city of Cherepovets (Vologda Region) so as to form among the youth the values of motherhood, fatherhood, responsible parenthood and preservation of reproductive health among the younger generation.

Materials and methods. The study of the problem of preserving the reproductive health in young people was carried out according to data from open sources of information and based on the personal experience of the authors. Six training seminars were held with the involvement of specialists in the field of psychosexual development of children and adolescents; 125 specialists working in the field of education and healthcare have been trained. To diagnose the readiness of students to implement the training program, a survey was conducted. As a result, a methodological manual was developed, which was tested in all schools of Cherepovets.

Results. It was found that the preparation of the youth of Cherepovets for the future family life is an integral part of the general system of education of the younger generations. There is a need for an integrated approach to the process of preparing young people for family life. It is shown that at the stage of school education, special programs for acquainting the younger generation with the issues of creating their own family in the future and fulfilling the duties of a spouse and parent in raising children are of particular importance. It has been established that the development and implementation of special programs in educational institutions to promote a value attitude to the family and marriage, the importance of motherhood and fatherhood, marriage, and the preservation of reproductive health can affect the formation of a new system of family values in modern society.

Conclusions. Within the framework of the model of network interaction of specialists regarding the formation of family values, responsible parenthood, and marriage among young people, the need to preserve reproductive health among young people and increase literacy in the matters of sexual education is shown.

Perm Medical Journal. 2023;40(4):111-119
pages 111-119 views

Clinical case

Clinical case of treatment of postoperative intestinal paresis in case of secondary diffuse peritonitis
Samartsev V.A., Gavrilov V.A., Kuznetsova M.P., Domrachev A.A., Pushkarev B.S.

One of the most common functional disorders in abdominal surgery during the early postoperative period is intestinal paresis. It accounts for 12 % of all types of intestinal obstruction. Postoperative intestinal paresis complicates significantly the course of the early postoperative period and greatly influences the outcome of the surgical intervention. All disorders of the motor and evacuatory function of the gastrointestinal tract, from insignificant discoordination of the motor function to paresis and paralytic obstruction, are often the leading cause of all kinds of postoperative complications. The clinical case of the treatment of the postoperative intestinal paresis using a saline enteral solution in a patient after repeated relaparotomies on the background of secondary peritonitis is presented. Efficiency of the postoperative paresis treatment was assessed by intra-abdominal pressure measurement, X-ray investigation and auscultatory peristalsis evaluation.

Perm Medical Journal. 2023;40(4):120-126
pages 120-126 views
Allergic bronchopulmonary aspergillosis (known unknown disease, analysis of clinical observation)
Barlamov O.P., Barlamov P.N.

To show an algorithm for diagnosing this disease and demonstrate the effectiveness of etiological treatment using the case history of a patient with allergic bronchopulmonary aspergillosis (ABPA) against the background of bronchial asthma (BA).

Complaints, anamnesis, physical status, laboratory and instrumental studies of a patient with ABPA are published. Modern literature data on the diagnosis and treatment of ABPA have been analyzed.

The complaints, anamnesis, physical status as well as laboratory and instrumental studies used for a patient with ABPA were analyzed in comparison with world literature data.

  1. Primary care physicians are informed insufficiently about the clinical picture of ABPA. 2. Antimycotic therapy with variconazole applied for patients with ABPA against the background of BA leads not only to positive morphological changes in the lungs but also to the relief of BA course.
Perm Medical Journal. 2023;40(4):127-134
pages 127-134 views
Clinical case: type II/IIIA mucolipidosis in a child
Balkunova Y.N., Kochergina E.A., Bazanova N.A.

Introduction. The problem of hereditary metabolic diseases remains relevant. Mucolipidosis (ML) is a hereditary, autosomal recessive orphan disease caused by a defect in the GNPTAB gene, which encodes alpha and beta subunits of the enzyme N-acetylglucosamine-1-phosphotransferase. Deficiency of this enzyme leads to the accumulation of acid hydrolases in the lysosomes of the liver, spleen, lung and brain cells. The disease is rare, has no pathognomonic symptoms at the initial stages and therefore deserves special attention of clinicians. Patients with ML are characterized by a special phenotype: multiple stigmas of dysembriogenesis, ricket-like skeletal changes, mental retardation. The diagnosis is confirmed by a genetic study.

Materials and methods. A case of type II/IIIA mucolipidosis in a three-year-old boy is presented.

Results. The diagnosis was made immediately after the birth, and confirmed by the age of 4 months. Since his birth, the child had a characteristic phenotype and changes in the internal organs: ventriculomegaly, bicuspid aortic valve, increased kidney size, gallbladder deformity, splenomegaly, as well as changes in the bone tissue. Up to the age of one year, the child did not suffer from respiratory infections, but significantly lagged behind in physical and psychomotor development. Acute respiratory viral infections with bronchoobstructive syndrome and pneumonia  after the age of one, sharply slowed down his development and worsened the course of the underlying disease. At the age of 3 years and 11 months, the child does not sit, does not stand, does not walk, does not control the functions of the pelvic organs, does not talk. In the recent months, there has been noted a violation of the act of swallowing and the child was gastrostomized.

Conclusions. The description of the  case is aimed at attracting the attention of pediatricians to the peculiarities of following up children with this pathology at the district polyclinic as well as  ensuring a multidisciplinary approach when monitoring a patient with accumulation diseases, and conducting timely specific preventive measures against intercurrent diseases (vaccination).

Perm Medical Journal. 2023;40(4):135-140
pages 135-140 views

Biology and experimental medicine

Induction of immune response caused by G-01 solution in laboratory animals with transplanted melanoma (B-16)
Garaishin R.M., Kzyrgalin S.R., Kitapova R.R., Kostromina D.A., Garaishina D.R., Zaleev T.R.

Objective. To study the properties of the immune response with G-01 solution at the example of melanoma (B-16).

Material and methods. Experiments were conducted on the offspring of heterosexual BALB/c aged 8 weeks. Groups of offspring were not separated by sex. In the work, a 20 % solution of G-01 was used, administered subcutaneously 0.5 ml 2 times a day for 2 days with the presence of an adjutant (aluminum hydroxide). In the first experiment, the solution was used as a prophylactic drug, in the second – as a therapeutic one, which was used on the 6th day after the transplantation of melanoma (B-16).

Results. In the first experiment, one month after the applied treatment scheme (prophylactic) with G-01 solution, an attempt was made to transplant the melanoma (B-16) subcutaneously to 10 mice of the main group. The control group consisted of 6 mice. After 3 weeks, an increase in the neoplasm of the right axillary region was detected in 2 mice of the main group. The neoplasm regressed during the next 3 weeks. In the control group, melanoma transferred in 5 out of 6 mice, with subsequent development of the disease and fatal outcome on average on the 60th day of the disease. In the second experiment, two groups (10 animals each) were analyzed: control and main. The tumor transferred in 100 % of cases in both groups. The injected solution on the 6th day after the transplantation of melanoma (B-16) did not affect the growth of the tumor. Mice died in both groups. The average duration of life in both groups was 36 and 38 days, respectively. There were no statistically significant differences in the groups.

Conclusions. The prospect of using G-01 solution in medicine as a preventive agent of natural origin was established. This method of inducing an immune response with G-01 solution can be used to prevent the development of a solid tumor of melanoma B-16. The subcutaneously injected 20 % solution of G-01 – 0.5 ml 2 times a day for 2 days – has no effect on melanoma on the 6th day after the transplantation.

Perm Medical Journal. 2023;40(4):141-146
pages 141-146 views


Historic dates of “Perm Medical Journal”: the hundredth anniversary of “Perm Medical Journal”
Khlynova O.V., Bulatova I.A.

In 2023, the Perm Medical Journal celebrates its centenary. The history of the creation of the first specialized medical publication in the Urals is given. The journal was created at a difficult time for the country. But already in 1923, the founders of the journal understood its necessity and significance for the medical science of the Ural region. The contents of the journal, as today, included original research, reviews and abstracts, analysis of clinical cases, coverage of the activities of scientific societies and an extensive chronicle. The pages of the journal covered issues of theoretical, clinical and social medicine, organization of healthcare, training of medical personnel, development and formation of the resorts in the Urals. Works of Perm scientists on the most pressing problems of science and health care in the Western Urals were published. The mission of the Perm Medical Journal is now to accumulate and disseminate modern scientific knowledge, the results of fundamental and applied scientific research among medical specialists in order to ensure integration into the global scientific community, exchange experience and maintain a high level of qualification of doctors and researchers. The journal allows authors to publish scientific results and provides access to private content that promotes the global exchange of knowledge and experience.

Perm Medical Journal. 2023;40(4):147-153
pages 147-153 views
Professor Emil Moiseevich Zalkind – the 125th anniversary of his birth
Utochkin Y.A., Fedorova A.A., Suyundukova V.V.

The article is devoted to the 125th anniversary of the birth of Zalkind Emil Moiseevich – Doctor of Medical Sciences, Professor of the Department of Psychiatry and Head of the Psychiatric Clinic of Perm Medical Institute. In 1922, he graduated from the Medical Faculty of Don University and began to work as a resident of the Neuropsychiatric Clinic of the North Caucasian Medical Institute in Rostov-on-Don, where he served until 1932. Emil Moiseevich is the author of more than 100 scientific papers devoted to the problem of mental disorders in encephalopathies. Professor Zalkind was an initiator of the creation of the Ural Research Psychoneurological Institute. He was awarded the Order of the Badge of Honor. In addition to medicine, Emil Moiseevich was fond of music; he graduated from Saratov Philharmonic (a piano class, the composer Glier) and received higher musical education. For his great achievements in medicine, E.M. Zalkind was awarded the title of the Honored Scientist of the RSFSR.

Perm Medical Journal. 2023;40(4):154-157
pages 154-157 views
The 130th anniversary of the birth – Ezhov Nikolay Nikolaevich, the first head of the Department of Physics of Izhevsk State Medical Institute, a native of Perm Province
Popova N.M., Yezhov A.V., Starovoitov S.O., Yudintseva I.V.

The article describes the life, scientific, professional path of the Associate Professor, the first Head of the Department of Physics of Izhevsk State Medical Institute, a teacher and public figure Nikolay Nikolaevich Ezhov.

Perm Medical Journal. 2023;40(4):158-163
pages 158-163 views

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