Perm Medical Journal

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The peer-review scientific and practical bimonthly medical journal.

Editor-in-Chief

Olga V. Khlynova, MD, Dr. Sci. (Medicine), Corresponding Member of the Russian Academy of Sciences (Wagner State Medical University).
ORCID iD: 0000-0003-4860-0112 

Publisher

Eco-Vector (WEB: www.eco-vector.com)

Founders

The periodical "Perm Medical Journal" is registered with the Federal Service for Supervision of Communications, Information Technology and Mass Communications (Roskomnadzor). Media Registration Certificate ПИ № ФС 77 - 70264 от 13.07.2017.

The online publication "Pharm medical journal" is registered with the Federal Service for Supervision of Communications, Information Technology and Mass Communications (Roskomnadzor). The certificate of registration of mass media ЭЛ № ФС 77 - 75489 от 05.04.2019.

About

The journal was founded in 1923 by Medical Society of Perm University (ISSN Key title: Permskiĭ medit︠s︡inskiĭ zhurnal). The journal publish original researches and reviews, case reports and short communications on the following science fields:

  • Obstetrics and Gynecology
  • Oncology, X-ray therapy
  • Surgery
  • Endocrinology
  • Pediatrics
  • Pulmonology
  • Epidemiology
  • Clinical laboratory diagnostic

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Current Issue

Vol 42, No 3 (2025)

Full Issue

Review of literature

Sarcopenia as a complication of type 1 diabetes mellitus
Makarova O.B., Lyapunova A.I., Suplotova L.A., Alieva O.O.
Abstract

The objective of this review is to systematize and summarize the available literature data on the problem of sarcopenia in patients with type 1 diabetes mellitus (DM 1). Sarcopenia is a progressive and generalized disease characterized by loss of muscle mass, strength, and decreased skeletal muscle function. More and more data reflecting the deterioration of a muscle mass condition and decreased muscle function and strength in patients with DM 1 have accumulated over the past few years. A hypothesis concerning impaired muscle condition and function in young patients with DM is put forward, thus, diabetic sarcopenia can be considered as a direct complication of DM 1.

Currently, diagnostics is based on the clinical algorithm proposed in the consensus of the European Working Group on Sarcopenia in Older People in 2019 (EWGSOP2). Despite numerous studies on sarcopenia, the issue of validated biomarkers used for early diagnosis and monitoring of sarcopenia remains unresolved.

Perm Medical Journal. 2025;42(3):5-16
pages 5-16 views
Types of cardiac arrhythmias in patients with myocardial infarction
Orekhova Y.N., Rodionov R.A., Khlynova O.V., Karpunina N.S.
Abstract

Cardiac arrhythmias complicate the course of myocardial infarction (MI) in more than half of cases. Due to the availability of modern reperfusion methods and their timely implementation, it was possible to improve both immediate and long-term results of treatment in patients with MI. However, some types of arrhythmias, both supraventricular and ventricular, complicating MI, are still associated with unfavorable outcomes, including increased mortality. A systematization of modern data on the types of cardiac arrhythmias developing in patients with MI and affecting the prognosis is presented in the article. Available publications by Russian and foreign authors from such databases as the eLibrary.ru, PubMed, were used to prepare the work.

Perm Medical Journal. 2025;42(3):17-28
pages 17-28 views
Multiple sclerosis in women: features of the course at different stages of fertile function
Kicherova O.A., Akhmedova I.N., Reikhert L.I., Shevlyukova T.P., Bulatova I.A.
Abstract

Multiple sclerosis (MS) is a chronic dysimmune neurodegenerative disease that predominantly affects young women, has a high risk of disability and significantly impairs the quality of life. Considering the high medical and social significance of multiple sclerosis, issues related to the management of the disease at different periods of a woman's life cycle deserve special attention.

The disease is associated with hormonal levels, its impact on fertility is discussed, as well as the risk of transmitting the disease to the offspring. The authors consider the course of MS in pregnant women, as well as approaches to pregnancy planning in patients receiving disease modifying drugs (DMD) for multiple sclerosis. The data on the prognosis of the disease in the near and late postpartum period are analyzed, and the features of the course of the disease during menopause are considered.

Studying the features of the disease course in women at different ages in relation to changes in hormonal levels contributes to a more complete understanding of its pathogenesis and treatment strategy.

Perm Medical Journal. 2025;42(3):29-41
pages 29-41 views
Problems and prospects for studying cancers on models of induced pluripotent stem cells
Kokaev R.I., Islaev A.A., Galamatova K.A., Vakhaeva K.M., Tabalaeva S.G., Bubaeva Z.K., Dudagova R.M., Tazbaeva R.S., Shapiyanova M.T., Kodzaeva I.A., Musaeva I.I., Karagodina E.A.
Abstract

Induced pluripotent stem cells (iPSCs) offer a number of new possibilities as a versatile tool for modeling various cancer types and for pharmacological testing. Researchers can generate iPSC-derived cancer cells to study tumorigenesis and the molecular mechanisms underlying various cancer types. This approach gives a unique opportunity to observe and manipulate cancer progression in a controlled environment.

Perm Medical Journal. 2025;42(3):42-57
pages 42-57 views
Hepatotropic therapy for drug-induced liver injury (expert meeting)
Okovityi S.V., Raikhelson K.L., Akhmedov V.А., Vologzanina L.G., Gladkov O.A., Grechishnikova V.R., Deeva T.А., Dolgushina A.I., Zharkova M.S., Kozlova I.V., Kondrashina E.A., Mayevskaya M.V., Marchenko N.V., Pazenko Y.V., Pirogova I.Y., Prashnova M.K., Prikhodko V.A., Tarasova L.V., Khlynov I.B., Khlynova O.V.
Abstract

A  joint council of experts in the field of hepatology reviewed the results of experimental and clinical studies evaluating the efficacy of hepatotropic drugs (ademetionine, ursodeoxycholic acid, ornithine, bicyclol,  morpholinium
tiazotate, phospholipids, a fixed combination of inosine + meglumine + methionine + nicotinamide + succinic acid), glucocorticoids, extracorporeal detoxification methods in drug-induced liver injury (DILI); inclusion of these medications and treatment methods in clinical guidelines in various countries was analyzed.

Indications for the use of hepatotropic drugs were formulated depending on the pattern of DILI (hepatocellular, cholestatic, mixed), as well as in some DILI phenotypes.

Perm Medical Journal. 2025;42(3):58-74
pages 58-74 views

Original studies

Hemorrhoids in pregnant and postpartum women: risk factors
Romanovskaya А.V., Parshin A.V., Arzhaeva I.А., Karagyozyan K.M.
Abstract

Objective. To investigate the main risk factors and symptoms of hemorrhoids in maternity patients in the postpartum department of the PC of the Saratov region for the period from 2021 to 2022 by means of anonymous questionnaire.

Materials and methods. Patients were categorized into 3 groups according to receipt of progesterone therapy during the last pregnancy: In Group I, pregnant and postpartum women did not receive hormonal therapy (n=114). Group II included pregnant and postpartum women who received progesterone during their pregnancy for not more than 1 trimester (n=64). Group III consisted of pregnant and postpartum women whose pregnancy resulted from IVF. They received progesterone therapy for 2 or more trimesters (n=36).

Results. The study revealed that hemorrhoid symptoms were statistically more frequent in the women from group III, who had received progesterone hormone therapy for more than 2 trimesters. The most significant risk factors for the development of hemorrhoids in pregnant and postpartum women were: natural delivery: the number of births 3 and more; prolonged gestagens intake; tendency to constipation; positive family history of hemorrhoidal and varicose diseases.

Conclusions. Unfortunately, hemorrhoids in pregnant and postpartum women is still an urgent problem of interdisciplinary control of proctologic complaints in pregnant and postpartum women. Most physicians do not give recommendations on the present symptomatology in women.

Perm Medical Journal. 2025;42(3):75-85
pages 75-85 views
On the issue of adrenalectomy using videoendoscopic approaches in adrenocortical cancer
Krivosheev A.V., Britvin T.A., Babaeva H.G.
Abstract

Objective. To evaluate the results of adrenalectomies which were performed using endoscopic approach in surgical treatment of adrenocortical cancer.

Materials and methods. The results of surgical treatment of 58 patients with stage I-III adrenocortical cancer were studied from 1998 to 2024. A single-center retrospective controlled cohort study was conducted. The main group consisted of 23 patients who underwent adrenalectomy using video endoscopic access. Intra- and postoperative complications, disease-free and overall survival rates of patients were studied. The comparison group included 35 patients whose surgical treatment was performed via the traditional "open" approach.

Results. The median tumor size in patients of the main group was 4.8 cm [3.7; 6.1], and the maximum tumor size was 13 cm. In the comparison group, these parameters were 8 cm [6; 12] and 19 cm. There were neither intraoperative complications, nor cases of tumor capsule integrity disruption in both groups. While analyzing postoperative complications, grade I complications according to the Clavien-Dindo classification were revealed in 2 patients of the main group. In the comparison group 4 patients had grade I complications, 1 patient had grade IIIb complication, and grade V complication developed in 1 case. Morphological examination confirmed the resection status of R0 in all patients. In the study group, the median Weiss index was 4 [4; 5] points, and the median Ki67 expression level was 12% [7; 19.5]. In the comparison group, these indicators were higher – 6 [5; 6] points and 22% [11.5; 26]. The 5-year disease-free survival rate in the main group was 77 %, the overall 5-year survival rate was 83 %, and in the "open" surgery group, long-term outcomes were significantly worse: 51% (p=0.046) and 64% (p=0.037), respectively.

Conclusions. Video-endoscopic surgery can be considered as an effective method of treatment for patients with adrenocortical cancer, if there is no invasion into adjacent organs or regional lymph nodes metastases (in stage T1-3N0M0 according to ENSAT). Moreover, the tumor size in these cases is not a crucial factor when selecting the surgical approach. The absence of non-radical resections, satisfactory immediate results, favorable survival rates in patients of the study group with tumors more than 6 cm in size, confirmed this fact.

Perm Medical Journal. 2025;42(3):86-95
pages 86-95 views
Comparative effectiveness of computer optical topography and clinical photogrammetry in assessing spinal deformity in adolescents: results of a prospective study
Shitoev I.D., Muravyev S.V., Karakulova Y.V., Kloyan G.Z., Chaynikov P.N., Kovalev M.A.
Abstract

Objective. To study the diagnostic representativeness of ScolView™ clinical photogrammetry compared to the results of computer optical topography.

Materials and methods. The study material included protocols for the functioning of computer optical topography and ScolView™ for 160 participants of both sexes with an average age of 8 ± 0.78 years.

 Results. Despite the excellent physical principles of the methods, the ScolView™ outputs have a significant number of reliable correlations that lend themselves to logical clinical interpretation. The study data determined a total of 54 reliable Spearman criteria in the range of 0,712–0,800 when comparing the output data of both methods in three planes.

Conclusions. The work carried out is pioneering and at the same time prospective – for the purpose of a deeper analysis of the output data of ScolView™ with the segregation of the participants into comparison groups depending on the severity of spinal deformity.

Perm Medical Journal. 2025;42(3):96-108
pages 96-108 views
Experimental evaluation of the effect of porphyrins in antimicrobial photodynamic inactivation of burn wounds
Kvashnina D.D., Shirokova I.Y., Belyanina N.А., Syrbu S.А., Lebedeva N.S., Boeva Z.V., Burashnikova A.А., Kovalishena O.V., Saperkin N.V., Lazarev D.K.
Abstract

Objective. To studyandevaluate the effect of porphyrinson the microbialcontamination of infectedburnwounds in experimentalanimalsduringantimicrobialphotodynamicinactivation(PDI).

Materials and methods. Objects: asymmetric water-soluble porphyrins containing heterocyclic fragments on the periphery of the porphyrin cycle: benzoxazole residues (O-por), N-methyl benzimidazole (N-por) and benzothiazole (S-por). Animals: white mongrel Wistar rats weighing 250-300 g. (males, n=20), which received a III-degree contact burn contaminated with a test strain of S. аureus ATCC 29213. All animals are divided into four groups: No. 1 - PDI with O-por (n=5); No.2 – PDI with S-por (n=5); No. 3 – PDI with N-por (n=5); No. 4 (control) – PDI with 0.9% sterile sodium chloride solution (n=5). PDI parameters: LED light source (white light), maximum power: 20 W, maximum luminous flux: 1500-1800 lm, photo-irradiation time: 10 minutes. Two PDI sessions were conducted. Microbial contamination of wounds was studied in microbiological examination of wound discharge. The results of the microbiological study were qualitative (isolation of the causative agent of infection, its identification) and quantitative (determination of the number of colony-forming units (CFU/ml)). To evaluate the effectiveness of PDI, the values of the coefficient of logarithmic decrease in CFU of isolated microorganisms were calculated. Statistical data processing was performed in the R 4.2.1 environment (Rstudio 1.1.463).

Results. There was a decrease in the titer of microorganisms after the first and second sessions of PDI for all the studied compounds. The change in wound contamination towards pathogen clearance on the first day of the experiment was statistically significant for all porphyrin compounds tested (O-por p=0.0126;
S-por p=0.0377; N-por p=0.0128)comparedwith the controlgroup.According to the indicator, allthreetypes of porphyrinsshowed an efficiency of ≥90%.Thelogarithmicdecrease in CFUrangedfrom1to2dependingon the porphyrincompound,whichcorresponds to the inactivationof90to99% of microorganismsin the biomaterial.

Conclusions. The largest and statistically significant decrease in the number of microorganisms was observed in the groups of animals in which photosensitizers with heterocyclic fragments of benzimidazole
(N-por) and benzothiazole (S-por) were used, the indicators of logarithmic decrease in CFU was 2 (p=0.0065) and 1.3 (p=0.0232), respectively.

Perm Medical Journal. 2025;42(3):109-119
pages 109-119 views
Features of certain indicators of the vascular-platelet component of hemostasis and systemic inflammation markers in patients with inflammatory bowel diseases and non-alcoholic fatty liver disease
Trapeznikova A.А.
Abstract

Objective. To assess the levels of homocysteine, thrombocytes and indicators of systemic inflammation in patients with inflammatory bowel disease, non-alcoholic fatty liver disease and their combination depending on the severity and phenotype of the disease.

Materials and methods. A total of 62 patients with non-alcoholic fatty liver disease (NAFLD), ulcerative colitis (UC), Crohn's disease (CD) at the onset and exacerbation of the disease were examined. The following hemostasis parameters were studied: vascular (homocysteine) and platelet (platelet count). The levels of CRP, fibrinogen, α-1 and α-2 globulin were assessed as markers of systemic inflammation.

Results. The CRP value in the IBD and NAFLD group was 4.4 times higher than in patients of the NAFLD group, p=0.03, and 1.8 times higher than in patients with IBD, p=0.121. No significant differences in acute phase protein levels were revealed in the IBD and NAFLD groups. No changes were observed depending on the disease phenotypes either. The proportion of individuals with hyperhomocysteinemia was 2.4 times higher in the IBD+NAFLD group than in patients with isolated NAFLD, p=0.055. A correlation between the homocysteine ​​level with the NAFLD phenotype and the homocysteine ​​level with the severity of an IBD attack was detected. In patients with IBD, the homocysteine ​​level correlated with the marker of systemic inflammation (a-1 globulin), r = 0.587, p = 0.05. Platelet values ​​were significantly higher in individuals with combined pathology of IBD and NAFLD than in patients of the group with isolated NAFLD, p = 0.000. There were no differences in platelet levels depending on the phenotypes of IBD and NAFLD.

Conclusions. The homocysteine ​​level and platelet count in patients with associated course of IBD + NAFLD are higher than those in the isolated groups. Moreover, the values correlate with the severity of an IBD attack and the degree of systemic inflammation and depend neither on IBD phenotype nor on NAFLD phenotype.

Perm Medical Journal. 2025;42(3):120-129
pages 120-129 views

Methods of diagnosis and technologies

Possibility of predicting the probability of thyroid cancer recurrence by machine learning methods
Barulina M.А., Bendik I.Y., Kovalenko I.I., Polidanov М.A., Petrunkin R.P., Kudashkin V.N., Volkov K.А., Kravchenya A.R., Maslyakov V.V., Kapralov S.V., Aslanov H.E., Losyakova Y.V., Obukhov I.S., Osina A.D., Kurmaeva A.K.
Abstract

Objective. To develop a machine learning model for predicting the fact of recurrence in patients with thyroid cancer after surgical intervention.

Materials and Methods. According to the aim of the study, the case histories of 300 patients who had undergone surgical intervention for thyroid cancer were analyzed. The average age was 43.54 years. All patients included in the study underwent a comprehensive examination according to the clinical recommendations on the diagnosis and treatment of patients with thyroid cancer. Selection of the most appropriate model in machine learning is critical as it directly affects the accuracy and efficiency of prediction. Selection of the best model was done through comparing the performance of different algorithms on the same training sample using cross-validation. Each model was evaluated on such metrics as average accuracy and standard deviation to determine which model demonstrates the best results.  The random forest model performed best in terms of average accuracy and was used hereafter. The model was trained using a matrix of predefined features. Using param grid, we can efficiently adjust hyperparameters such as the number of trees, maximum depth and minimum number of samples for separation, which will help us to find the optimal settings for our task. RandomizedSearchCV method was used to select the hyperparameters. During the hyperparameter search process, the model was trained on training data selected as 70% of the original dataset. The search resulted in the following best hyperparameters for the random forest model for our data specifically: n_estimators = 161; min_samples_split = 5; max_leaf_nodes = 39; max_depth = 12; bootstrap = True.

 Results. A model that demonstrated high target feature accuracy was trained during the study. The proportion of patients with postoperative recurrence correctly identified by the model was 98 % of all patients with recurrence, and the proportion of patients without recurrence correctly classified by the model «as patients at no risk of recurrence» was 95 % of all patients without recurrence. This shows that the developed model effectively handles the task of classification based on medical parameters, which may be particularly important for decision making in clinical practice. The high accuracy indicates the reliability of the model and its ability to identify cases of recurrence correctly, this may contribute to the improvement of diagnostics and treatment.

Conclusions. A machine learning model to predict a high probability of thyroid cancer recurrence based on the analysis of medical parameters was developed while carrying out the study. The development process began with careful data preprocessing, which is a critical step in reliable models’ construction. During preprocessing, outliers and columns containing monotonic values were removed to improve the data quality and avoid distortions in the model training. Categorical variables were also coded to ensure that they could be used correctly in machine learning algorithms, and correlated features were excluded to minimize multicollinearity and increase the interpretability of the model.

Perm Medical Journal. 2025;42(3):130-143
pages 130-143 views
Determination of the location of the temporomandibular joint disc during magnetic resonance imaging visualization
Postnikov M.A., Afanasieva O.E., Nesterov A.M., Slesarev O.V., Postnikova E.M., Aleshkova I.V., Sargsyan K.T.
Abstract

Objective. To optimize the conditions for determining the location of the temporomandibular joint (TMJ) disc during magnetic resonance imaging (MRI) visualization.

Materials and methods. The analysis of MRI of the temporomandibular joints (TMJs) was performed using a 1.5 Tesla MRI scanner (Magnetom Vision, Siemens, Erlangen, Germany) equipped with a dual-channel coil designed for the TMJ. Each patient underwent a multi-plane examination consisting of nine images per joint, with a slice thickness of 2.5 millimeters.

Results. A method for diagnosing the intra-articular structures of the TMJ has been developed and implemented in clinical practice; the method is based on MRI of the joint in the oblique sagittal plane from both sides, in two different positions of the jaw, and a comprehensive criterion for the condition of the TMJ. The method has been validated on patients with TMJ dysfunction.

Conclusions. Due to a comprehensive assessment criterion of the TMJ condition and its visualization as a state diagram of intra-articular structures, it is possible to make prompt and reliable diagnosis of the status of these structures and develop an orthodontic and prosthetic treatment plan for patients.

Perm Medical Journal. 2025;42(3):144-153
pages 144-153 views

Preventive and social medicine

Current features of the epizootiological and epidemiological situation of Crimean hemorrhagic fever in the Rostov region
Logvin F.V., Kovalev E.V., Erganova E.G., Nenadskaya S.А., Leonenko N.V., Koreneva A.D., Batashev V.V., Vodyanitskaya S.Y., Chernaya A.S., Voloshka A.A., Samsonova D.A.
Abstract

Objective. To identify the current features of the epizootiological and epidemiological situation of Crimean hemorrhagic fever (hereinafter referred to as CHF) in the Rostov region to improve the strategy of preventive (anti-epidemic) measures.

Materials and methods. The data from the Reference Center for monitoring the causative agent of CHF of the Federal Medical Institution Stavropol Anti-Plague Institute of Rospotrebnadzor and the Office of Rospotrebnadzor in the Rostov region are used in the work. Methods of epidemiological analysis, laboratory diagnostics, statistical methods were applied.

Results. The data on the epizootic activity of natural foci of CHF in the Rostov region in recent years were obtained, the features of the natural foci formation were analyzed, the main sources and carriers of the infectious agent were determined, and the epidemiological profile of the epidemic process of CHF in the Rostov region was compiled. A conditional classification of municipal divisions of the Rostov region (cities and districts) according to the degree of epidemic activity has been developed and proposed.

Conclusions. As a result of the studies, the main current features of epizootic and epidemic processes of CHF in the Rostov region were identified, considering them an additional complex of preventive (anti-epidemic) measures aimed at preventing the population morbidity with CHF was proposed. It was determined that 40 administrative territories out of a total 55 of the region were involved in the epidemic process, the expansion of the endemic area (nozoareal) of the natural focus was proved.

Perm Medical Journal. 2025;42(3):154-163
pages 154-163 views
Analysis and assessment of morbidity with temporary disability among locomotive crew members in the Perm region in 2019–2024
Malyutina N.N., Shilkova O.Y., Sheludko V.S.
Abstract

Objective. To analyze morbidity among locomotive crew members with temporary disability from 2019 to 2024 in order to determine time series indicators and predicting disease incidence for 2025.

Materials and methods. The disease incidence assessment with temporary disability in the employees of the Perm division of Sverdlovsk Railway service of “JSC Russian Railways” is based on the data of Federal Statistical Observation Form № 19-VN. Statistical processing was carried out on a personal computer using spreadsheet program Excel® 2016 and calculation of time series indicators for the expected values in 2025.

Results. The most frequently occurring diseases of the respiratory, digestive and circulatory systems by the number of total days and incidence assessing morbidity among locomotive crew members were determined.

Conclusions. Respiratory diseases rank first in all indicators. An increase in disease incidence in all groups is observed mostly in 2021 and 2022 which we consider to be associated with coronavirus infection and its complications. For 2025 a rise in the absolute number of cases of respiratory and digestive diseases is expected and an increase in the number of absolute days is projected for respiratory diseases. In 2025, an increase in the incidence rate per 100 employees is projected for respiratory and digestive system diseases. A decrease in the incidence of respiratory diseases by 12,6% (or 8,2‰), digestive diseases by 40,43% (or 1,9‰), and circulatory diseases by 36,54% (or 1,9‰) was determined while analyzing morbidity (per 100 employees) in 2019 – 2024. The rate of increase or decrease in the incidence of all diseases varied unevenly from year to year.

Perm Medical Journal. 2025;42(3):164-171
pages 164-171 views

Clinical case

A clinical case of manifestations of dysgenetic polycystosis of the parotid salivary glands
Antakov G.I., Zotov D.A., Sultanova S.А., Rapekta S.I.
Abstract

A clinical case of a patient treated for a rare disease of dysgenetic polycystosis of the parotid salivary glands was analyzed.

Patient S., a 46-year-old man, was treated in the department of maxillofacial surgery from 25.11.24 to 02.12.24. Over the past 5 years, he noted a painless enlargement of the parotid salivary glands, which was confirmed by the clinical examination. The diagnosis of polycystosis of parotid salivary gland was confirmed histologically. Recommendations on the treatment strategy for patients with dysgenetic polycystic disease are proposed.

Perm Medical Journal. 2025;42(3):172-178
pages 172-178 views
Successful endovascular explantation of an IVC filter from the heart chamber of a patient with PE
Kadyraliev B.K., Kalysov K.A., Eraliev T.K., Norov F.K., Zhanbayev A.S., Abdimitalip Z., Satybaldiev А.T., Kdralieva N.V.
Abstract

The migration of the IVC filter into the heart chamber is a rare and dangerous complication. There are few data describing the successful treatment of this pathology in the world literature. The use of open surgery with the initiation of cardiopulmonary bypass is the "gold standard", however, the initial condition of patients and concomitant pathology can worsen the outcomes of treatment. The endovascular approach to such patients is the optimal method. Endovascular explantation of a migrated IVC filter is feasible, but readiness of the cardiac team is a key factor.

Perm Medical Journal. 2025;42(3):179-186
pages 179-186 views

Anniversaries

The contribution of perm scientists to the development of medical microbiology. On the 125th anniversary of professor A.V. Pshenichnov
Gorowitz E.S., Kuziaev R.Z., Maslov Y.N., Kuznetsova M.V.
Abstract

March 23, 2025 marked the 125th anniversary of Professor A.V. Pshenichnov, the founder of the Perm microbiological school, Honored Scientist, and Laureate of the State Prize. The article provides a historical overview on the main scientific achievements of Professor A.V. Pshenichnov and his students. His most significant researches are in the field of rickettsiosis, in particular epidemic typhus and Volyn fever, as well as tick-borne encephalitis. He and his colleague B.I. Raikher were awarded the State Prize for the development of a vaccine for the prevention of epidemic typhus, which played a decisive role in the fight against this disease during the Great Patriotic War. Students and followers of Professor A.V. Pshenichnov continue the traditions established by him as a long-term head of the department. At present, the department staff, together with specialists in various fields, are conducting successful researches on current issues of medical microbiology.

Perm Medical Journal. 2025;42(3):187-195
pages 187-195 views
Professor Adelaida Ivanovna Egorova: contribution to the development of pediatrics and pediatric education in the Perm region (on the occasion of the 100th anniversary of her birth)
Utochkin Y.A., Vardanyn M.G., Gusev V.A., Alekseev I.D.
Abstract

The article is dedicated to the 100th anniversary of the birth of Adelaida Ivanovna Egorova, Doctor of Medicine, Professor, Head of the Department of Faculty Pediatrics. She was born and raised in the Perm region. After graduating from Perm Medical Institute, she advanced from a resident to a chief physician. She was offered a position at the Department of Pediatrics, was actively engaged in scientific work, and defended her doctoral thesis. In addition, Adelaida Ivanovna was an active public figure, she was a member of the district council of the city, and headed the regional society of pediatricians.

Perm Medical Journal. 2025;42(3):196-199
pages 196-199 views